Treatment of actinic keratoses and cancerization field of the face and scalp with 0.015% ingenol mebutate gel in Brazilian individuals: safety, tolerability and patients' perspectives
Treatment of actinic keratoses and cancerization field of the face and scalp with 0.015% ingenol mebutate gel in Brazilian individuals: safety, tolerability and patients' perspectives
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DOI：
10.1590/abd1806-4841.20197938
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发表时间：
2019-05-01
影响因子：
1.7
通讯作者：
Aprahamian, Ivan
中科院分区：
文献类型：
--
作者：
Gameiro, Luiz;Tovo, Luis Fernando Requejo;Aprahamian, Ivan
背景：光化性角化病（AK）代表了进展为鳞状细胞癌的风险。巨大戟醇甲基丁酸酯凝胶是一种新的治疗选择，现场定向treatment. Accuratives：评估安全性，耐受性和患者的观点，与治疗成功的管理AK在面部和头皮巨大戟醇甲基丁酸酯凝胶在巴西个人。这是一个观察，回顾性和描述性研究，共涉及37名患者，其中68个区域的面部和头皮光化性角化病接受了Ingenol甲基丁酸酯凝胶治疗。在25 cm（2）的面积上连续三天应用药物，并在基线和第4、8、15、60和180天进行记录。在第4天，计算复合局部皮肤反应评分。在结束时，问卷调查，以评估患者的观点的treatment.RESULTS：坚持是100%，没有严重的不良事件记录和平均复合局部皮肤反应评分（标准差）为8.61 +/- 4.22。治疗被认为是最佳的75.68%的patients.Study限制：计算复合局部皮肤反应评分仅在第四天进行。结论：巨大戟醇甲基丁酸酯凝胶治疗被认为是安全和耐受的巴西科目。患者的依从率最高，自尊心也有很大的提高。这项研究的结果再现了文献的调查结果。
BACKGROUND: Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment.OBJECTIVES: To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and scalp with ingenol mebutate gel in Brazilian individuals.METHODS: This was an observational, retrospective and descriptive study of 68 areas of actinic keratosis on the face and scalp treated with Ingenol mebutate gel involving a total of 37 patients. The drug was applied for three consecutive days on an area of of 25 cm(2) and documentation was performed on baseline and days 4, 8,15, 60 and 180. On day 4, the composite local skin reaction score was calculated. At the end, a questionnaire was applied to evaluate patients' perspectives about the treatment.RESULTS: Adherence was 100%, no serious adverse events were recorded and the mean composite local skin reaction score (standard deviation) was 8.61 +/- 4.22. The treatment was considered optimum by 75.68% of the patients.STUDY LIMITATIONS: Calculation of composite local skin reaction score performed only on the fourth day.CONCLUSIONS: Treatment with ingenol mebutate gel was considered safe and tolerable in Brazilian subjects. Patients had a maximum adherence rate and a great improvement in self-esteem. The results of this research reproduce the findings of the literature.