COMPARISON OF PHARMACOKINETICS OF GLIPIZIDE AND GLIBENCLAMIDE IN MAN
COMPARISON OF PHARMACOKINETICS OF GLIPIZIDE AND GLIBENCLAMIDE IN MAN
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DOI：
10.1007/bf00616416
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发表时间：
1975-01-01
影响因子：
2.9
通讯作者：
ZAHND, GR
中科院分区：
文献类型：
--
作者：
BALANT, L;FABRE, J;ZAHND, GR
4例受试者口服5 mg 14 C-格列吡嗪，3例受试者静脉注射1 mg 14 C-格列本脲，2例受试者口服5 mg 14 C-格列本脲。测量血浆放射性水平以及尿液和粪便排泄。对于两种药物，血浆中放射性的消失遵循复杂的动力学，表观半衰期随时间稳定增加。这两种磺酰脲类药物被广泛代谢，并以羟基化或结合代谢产物的形式经尿液排泄。两种药物对血糖和免疫反应性胰岛素的影响相当。研究结果与其他已发表的结果进行了比较。
Four subjects received 5 mg14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-lives increased steadily with time. The two sulfonylureas were extensively metabolized and were excreted in the urine as hydroxylated or conjugated metabolites. The effects of both drugs on blood glucose and immunoreactive insulin were comparable. The findings are compared with other published results.