EFFECTS OF EFFERENT VAGAL STIMULATION ON ATRIAL AND VENTRICULAR FUNCTION
EFFECTS OF EFFERENT VAGAL STIMULATION ON ATRIAL AND VENTRICULAR FUNCTION
复制标题
DOI：
10.1152/ajplegacy.1968.215.5.1210
复制
发表时间：
1968-01-01
影响因子：
--
通讯作者：
REEVES, TJ
中科院分区：
文献类型：
--
作者：
HARMAN, MA;REEVES, TJ
材料与方法12只成年杂种犬，体重15 ~ 25 kg，用氯氯蔗糖（70 mg/kg）和脲聚糖（250 mg/kg）混合温药麻醉。呼吸由一个正压呼吸器（哈佛）通过一个带口的气管内管利用富氧室内空气维持。行胸骨正中切开术，在给予肝素（4”g/kg）后，开始标准右心搭桥手术，如下所述。根据需要给予氯安定比混合物和肝素额外剂量，以维持足够的麻醉和抗凝水平。结扎奇静脉，并在肺动脉主动脉和各腔心包外部分周围结扎。通过右心房切开单独插管，并在右心室刺伤后将插管固定在肺动脉主动脉中。静脉回流，通过重力引流收集在储液器中，通过一个校准的滚轴泵通过热交换器回流到肺动脉主动脉（Sarnes）。冠状动脉流出物通过重力从通过右心室第二处刺伤插入的排污管流入同一储存库。
MATERIALS AND METHODSTwelve adult mongrel dogs, weighing 15-25 kg, were anesthetized with a warmed mixture of chloralose (70 mg/kg) and urethan (250 mg/kg). Respiration was maintained by a positive-pressure respirator(Harvard) through a cuffed endotracheal tube utilizing oxygenenriched room air. A median sternotomy was performed and, following the administration of heparin (4 “g/kg), a standard right-heart bypass procedure was initiated as described below. Additional doses of the chloraloseurethan mixture and heparin were administered as needed to maintain adequate levels of anesthesia and anticoagulation.The azygos vein was ligated and ligatures placed about the main pulmonary artery and the extrapericardial portions of each cava. The cavae were individually cannulated through a right atriotomy, and a cannula secured in the main pulmonary artery following placement through a stab wound in the right ventricle. Venous return, collected in a reservoir via gravity drainage, was returned through a heat exchanger to the main pulmonary artery by a calibrated roller pump (Sarnes). Coronary effluent was led to the same reservoir by gravity from a sump line inserted through a second stab wound in the right ventricle.