Sendai viral vector mediated angiopoietin-1 gene transfer for experimental ischemic limb disease
Sendai viral vector mediated angiopoietin-1 gene transfer for experimental ischemic limb disease
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DOI：
10.1007/s10456-009-9144-6
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发表时间：
2009-09-01
期刊：
影响因子：
9.8
通讯作者：
Hamada, Hirofumi
中科院分区：
文献类型：
--
作者：
Huang, Jianhua;Inoue, Makoto;Hamada, Hirofumi
Sendai virus vector is emerging as a promising vector for gene therapy, and angiopoietin-1 (Ang-1) has been reported to improve the blood flow recovery in the ischemic limb or heart. In this study, we constructed a human Ang-1-expressing Sendai viral vector (SeVhAng-1) and injected it into the ischemic limb of rats. We found that SeVhAng-1 improved the blood flow recovery and increased the capillary density of the ischemic limb, compared with the controls. We also found that SeVhAng-1 increased p-Akt during the early period of limb ischemia, and decreased apoptosis in ischemic limb. It suggests that SeVhAng-1 may serve as a potential therapeutic tool in ischemic limb disease.
