Co-infection of SARS-COV-2 and influenza A virus: a case series and fast review
Co-infection of SARS-COV-2 and influenza A virus: a case series and fast review
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SARS-COV-2 和甲型流感病毒合并感染：病例系列和快速回顾
DOI：
10.22541/au.159103675.59631566
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
qiong zhou
中科院分区：
文献类型：
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作者：
Xuan Xiang;Zihao Wang;Xinliang He;Xiaoshan Wei;Yanling Ma;Hui Li;Long Chen;Xiaorong Wang;qiong zhou
背景：COVID-19已成为全球大流行病。对SARS冠状病毒2型与甲型流感病毒（IAV）在流感季节合并感染的研究将有助于对合并感染患者进行抗病毒干预。研究方法：回顾了武汉协和医院145例COVID-19患者的队列，我们发现2例患者同时感染SARS-CoV-2和IAV。然后我们从PubMed、Web of Science和CNKI中检索了从1月1日到5月1日的以下关键词："COVID-19，SARS-COV-2，influenza A and co-infection"，6篇研究被纳入本描述性分析。结果如下：13例合并感染患者中，2例来自武汉协和医院，11例来自PubMed、Web of Science和CNKI。在13例患者中，中位年龄为50岁（IQR，40.5 - 67.5）。13例患者中，7例（53.8%）为重型，7例为男性，5例有合并症。最常见的症状为咳嗽（100%）、发热（92.3%）和呼吸困难（76.9%）。8例患者入院时出现淋巴细胞减少，13例患者入院后首次检查均出现异常影像学改变。从症状发作到入院的中位时间为4.5天（IQR，2.75 - 5.5），中位住院时间为17天（IQR，15 - 20）。7例患者出院，其余6例患者的临床结局尚不清楚。结论：同时感染SARS-COV-2和IAV的患者与仅感染SARS-COV-2的患者在症状和影像学方面表现出相似的变化。在快速回顾中，SARS-COV-2合并IAV感染可导致更严重的临床状况，但与仅感染SARS-COV-2的患者相比，住院时间相似。
Background: COVID-19 has become a global pandemic. Studies about SARS-CoV-2 co-infection with influenza A virus (IAV) in the influenza season will contribute to the antiviral interventions of co-infected patients. Methods: A cohort of 145 COVID-19 patients in Wuhan union hospital were reviewed and we found 2 patients were co-infected with both SARS-CoV-2 and IAV. Then we searched from PubMed, Web of Science and CNKI with combinations of the following key words: “COVID-19, SARS-COV-2, influenza A and co-infection” from January 1 up to May 1, and 6 studies were included in this descriptive analysis. Results: Of the 13 co-infected patients, 2 were from Wuhan union hospital, another 11 were collected from the reports published on PubMed, Web of Science and CNKI. Of the 13 patients, the median age was 50 years (IQR, 40.5-67.5). Among the 13 patients, 7 (53.8%) were severe types, 7 were males and 5 had comorbidities. The most common symptoms among the 13 patients were cough (100%), fever (92.3%) and dyspnea (76.9%). 8 patients had lymphocytopenia on admission and all the 13 patients had abnormal radiological changes in their first examination after admission. The median time from symptom onset to hospital admission was 4.5 days (IQR, 2.75-5.5), and the median time of hospital stay was 17 days (IQR,15-20). 7 patients were discharged, and the clinical outcomes of the remaining 6 patients were unclear. Conclusion: Patients with both SARS-COV-2 and IAV infection showed similar changes in symptoms and radiological images with patients infected with SARS-COV-2 only. SARS-COV-2 co-infection with IAV can lead to more severe clinical condition but had similar hospital stay compared with patients infected with SARS-COV-2 only in the fast review.