Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays.
Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays.
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口腔鳞癌临床病理特征分析及组织芯片的建立
DOI：
10.3892/ol.2016.5120
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发表时间：
2016-11
期刊：
影响因子：
2.9
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Jin X;Liu D;Zhao X;Zhou Y;Jiang L;Li J;Zeng X;Chen Q
本研究的目的是评估大型中国患者队列中与口腔鳞状细胞癌（OSCC）致命结果相关的临床病理学危险因素，并利用该队列构建组织微阵列（TMA）。对 232 名 OSCC 患者进行单变量和多元 Logistic 回归分析，评估预后不良的预测因子，然后使用患者肿瘤组织构建 TMA。单因素logistic回归分析表明，OSCC的不良预后与男性、吸烟史、肿瘤淋巴结转移分期和淋巴结转移有关。多元逻辑回归分析表明，OSCC 患者死亡风险的增加与淋巴结转移显着且独立相关（比值比，3.421；95% 置信区间，1.609–7.273）。因此，本研究结果提示淋巴结转移是OSCC患者预后不良的独立危险因素。口腔鳞癌TMA构建成功，是中国大陆患者中首次报道的TMA。
The aim of this study was to evaluate clinicopathological risk factors associated with the fatal outcome of oral squamous cell carcinoma (OSCC) in a large cohort of Chinese patients, and to construct tissue microarrays (TMAs) using this cohort. Univariate and multiple logistic regression analyses were performed to evaluate the predictors of poor prognosis in a cohort of 232 patients with OSCC, after which the patient tumor tissues were used to construct TMAs. Univariate logistic regression analysis indicated that a poor outcome of OSCC was associated with the male gender, a history of smoking, the tumor-node-metastasis stage and lymph node metastasis. Multiple logistic regression analysis demonstrated that an increased risk of mortality in patients with OSCC was significantly and independently associated with lymph node metastasis (odds ratio, 3.421; 95% confidence interval, 1.609–7.273). Therefore, the results of the present study suggested that lymph node metastasis is an independent risk factor associated with a poor prognosis of OSCC patients. TMAs of OSCC were successfully constructed, and are the first TMAs to be reported in mainland Chinese patients.
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DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
DOI：
10.1016/j.ijrobp.2011.03.060
发表时间：
2011-11-15
影响因子：
7
作者：
Kang, Chung-Jan;Lin, Chien-Yu;Yen, Tzu-Chen
通讯作者：
Yen, Tzu-Chen
影响因子：
3.4
作者：
Grimm, M.
通讯作者：
Grimm, M.
影响因子：
4.8
作者：
Kang, Chung-Jan;Liao, Chun-Ta;Yen, Tzu-Chen
通讯作者：
Yen, Tzu-Chen