Specificity and Plasticity of Thalamocortical Connections in Sema6A Mutant Mice
Specificity and Plasticity of Thalamocortical Connections in Sema6A Mutant Mice
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DOI：
10.1371/journal.pbio.1000098
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发表时间：
2009-04-01
期刊：
影响因子：
9.8
通讯作者：
Mitchell, Kevin J.
中科院分区：
文献类型：
--
作者：
Little, Graham E.;Lopez-Bendito, Guillermina;Mitchell, Kevin J.
特定丘脑核团和皮质区之间的连接的建立涉及丘脑皮质轴突的指导和皮质区响应于适当的神经支配的阐述之间的动态相互作用。在这里，我们表明，Sema6A突变体提供了一个独特的模型来测试当前的想法之间的相互作用皮层下和皮层的指导机制和皮层区域化。在这些突变体中，来自背外侧膝状体核（dLGN）的轴突在腹侧端脑中被错误路由。这导致在胚胎阶段，躯体感觉丘脑轴突侵入假定的视觉皮层。值得注意的是，错误路由的dLGN轴突能够在出生后阶段通过替代路线找到通往视觉皮层的方式，并重建正常的丘脑皮层连接模式。这些研究结果强调的重要性和特异性的皮层线索在建立丘脑皮层连接和壮观的能力，出生后早期皮层重新映射初始的感觉表征。
The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations.