Tailored immunity by skin antigen-presenting cells
Tailored immunity by skin antigen-presenting cells
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DOI：
10.4161/hv.34299
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发表时间：
2015-01-01
影响因子：
4.8
通讯作者：
Combadiere, Behazine
中科院分区：
文献类型：
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作者：
Levin, Clement;Perrin, Helene;Combadiere, Behazine
皮肤疫苗接种旨在靶向表皮和皮肤抗原呈递细胞（APC），实际上，许多不同起源的子集都赋予了各种功能。皮肤可以代表一个特别有效的部位，以诱导牛ac疫苗通过皮肤疤痕疫苗接种成功后，出现了适应性和保护性免疫反应的想法。最近的进步表明，APC的多个亚群在皮肤中共存，并参与传染病的免疫力。自适应免疫反应的诱导取决于皮肤APC对抗原的初始识别和捕获，及其转运到淋巴机构。因此，已经开发出疫苗接种的创新策略来靶向皮肤APC以量身定制免疫，因此该评论将讨论对皮肤APC子集表征的最新见解以及它们如何塑造适应性免疫反应。
Skin vaccination aims at targeting epidermal and dermal antigen-presenting cells (APCs), indeed many subsets of different origin endowed with various functions populate the skin. The idea that the skin could represent a particularly potent site to induce adaptive and protective immune response emerged after the success of vaccinia virus vaccination by skin scarification. Recent advances have shown that multiple subsets of APCs coexist in the skin and participate in immunity to infectious diseases. Induction of an adaptive immune response depends on the initial recognition and capture of antigens by skin APCs and their transport to lymphoid organs. Innovative strategies of vaccination have thus been developed to target skin APCs for tailored immunity, hence this review will discuss recent insights into skin APC subsets characterization and how they can shape adaptive immune responses.