The Drosophila ARC homolog regulates behavioral responses to starvation
The Drosophila ARC homolog regulates behavioral responses to starvation
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DOI：
10.1016/j.mcn.2007.06.008
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发表时间：
2007-10-01
影响因子：
3.5
通讯作者：
Griffith, Leslie C.
中科院分区：
文献类型：
--
作者：
Mattaliano, Mark D.;Montana, Enrico S.;Griffith, Leslie C.
编码dARC 1的基因是哺乳动物活动调节细胞因子相关蛋白（ARC）的三个果蝇同源物之一，在癫痫发作和肌肉过度收缩突变体中均上调。在这项研究中，我们产生了一个无效突变体dArc1，并表明该基因不参与突触可塑性在幼虫神经肌肉接头或形成或衰减的短期记忆的求爱条件，而是一个修改器的压力诱导的行为。dARC 1在许多神经分泌细胞中表达，并且突变体是耐饥饿的，在没有食物的情况下表现出增加的存活时间。饥饿抗性可能是由于dArc1突变体缺乏对饥饿的正常超运动反应，这在动物界几乎是普遍的。dARC 1在大脑间部的胰岛素产生神经元中起作用以控制这种行为，但似乎不是胰岛素信号传导的一般调节剂。这表明，在控制饥饿诱导的行为反应的部分和环腺之间有多种模式的通信。(c)2007年爱思唯尔公司All rights reserved.
The gene encoding dARC1, one of three Drosophila homologs of mammalian activity-regulated cytoskeleton-associated protein (ARC), is upregulated in both seizure and muscular hypercontraction mutants. In this study we generate a null mutant for dArc1 and show that this gene is not involved in synaptic plasticity at the larval neuromuscular junction or in formation or decay of short-term memory of courtship conditioning, but rather is a modifier of stress-induced behavior. dARC1 is expressed in a number of neurosecretory cells and mutants are starvation-resistant, exhibiting an increased time of survival in the absence of food. Starvation resistance is likely due to the fact that dArc1 mutants lack the normal hyperlocomotor response to starvation, which is almost universal in the animal kingdom. dARC1 acts in insulin-producing neurons of the pars intercerebralis to control this behavior, but does not appear to be a general regulator of insulin signaling. This suggests that there are multiple modes of communication between the pars and the ring gland that control starvation-induced behavioral responses. (c) 2007 Elsevier Inc. All rights reserved.