Cerebellar dysfunction in essential tremor
Cerebellar dysfunction in essential tremor
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DOI：
10.1002/mds.26629
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发表时间：
2016-08-01
影响因子：
8.6
通讯作者：
Ugawa, Yoshikazu
中科院分区：
文献类型：
--
作者：
Hanajima, Ritsuko;Tsutsumi, Ryosuke;Ugawa, Yoshikazu
目的：一些神经生理学研究已经研究了特发性震颤患者的小脑功能，尽管小脑可能参与了震颤的产生。采用两种生理学方法对20例原发性震颤患者和30例年龄匹配的健康志愿者的小脑功能进行研究，并对结果进行组间比较。结果特发性震颤患者的小脑抑制和棱镜适应均受到影响。震颤的程度与异常程度无相关性。结论对上述结果最简单的解释是小脑本身，包括浦肯野细胞，参与了特发性震颤，这可能反映了原发病理性损害或继发性代偿生理现象。(C)2016国际帕金森病和运动障碍协会
ObjectivesFew neurophysiological studies have investigated cerebellar function in patients with essential tremor, even though the cerebellum may contribute to tremor generation. Here, we studied cerebellar function in patients with essential tremor using 2 physiological methods.MethodsParticipants were 20 patients with essential tremor and 30 age-matched healthy volunteers, and the results were compared across the groups. We studied motor cortical inhibition using cerebellar magnetic stimulation and prism adaptation.ResultsBoth cerebellar inhibition and prism adaptation were affected in patients with essential tremor. The degree of tremor did not correlate with the degree of abnormality in either of the 2 experiments.ConclusionsThe simplest explanation for the present results is that the cerebellum itself, including the Purkinje cells, is involved in essential tremor, which may reflect a primary pathogenic lesion or secondary compensatory physiological phenomenon to an original pathogenic lesion elsewhere. (c) 2016 International Parkinson and Movement Disorder Society