Alcohol consumption and Helicobacter pylori infection:: Results from the German National Health and Nutrition Survey
Alcohol consumption and Helicobacter pylori infection:: Results from the German National Health and Nutrition Survey
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DOI：
10.1097/00001648-199905000-00004
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发表时间：
1999-05-01
期刊：
影响因子：
5.4
通讯作者：
Boeing, H
中科院分区：
文献类型：
--
作者：
Brenner, H;Berg, G;Boeing, H
酒精有很强的抗菌活性，能刺激胃酸分泌。因此，饮酒可能损害胃中幽门螺杆菌的生存条件。我们在德国国家健康和营养调查中评估了1785名年龄在18-88岁的参与者中饮酒与幽门螺杆菌感染的关系。在个人访谈中使用标准化的食物频率问卷获得饮食和生活习惯的详细信息。采用酶联免疫吸附法检测血清中幽门螺杆菌免疫球蛋白G抗体。幽门螺杆菌感染的总患病率为39.2%。报告饮酒与幽门螺杆菌感染之间存在明显的剂量-反应反比关系。在排除潜在的混杂因素后，这种关系仍然存在。与不饮酒者相比，每天饮酒10克、10克至20克和超过20克的人幽门螺杆菌感染的调整患病率（95%置信区间）分别为0.93（0.77-1.13）、0.82（0.65-1.04）和0.71（0.55-0.92）。当有近期饮酒变化迹象的个体被排除在分析之外时，饮酒与幽门螺杆菌感染之间的负相关关系甚至更强。这些发现支持了适度饮酒可能促进成人幽门螺杆菌感染自发消除的假设。
Alcohol has strong antimicrobial activity and stimulates gastric acid secretion. Alcohol consumption may therefore compromise the living conditions of Helicobacter pylori in the stomach. We assessed the relation of alcohol consumption with H. pylori infection among 1,785 participants ages 18-88 in the German National Health and Nutrition Survey. Detailed information on dietary and lifestyle habits was obtained in personal interviews using a standardized food frequency questionnaire. Serum samples were analyzed for H. pylori immunoglobulin G antibodies by enzyme-linked immunosorbent assay. Overall prevalence of H. pylori infection was 39.2%. There was a clear inverse dose-response-relation between reported alcohol consumption and H, pylori infection. The relation persisted after control for potential confounding factors. The adjusted prevalence ratios (95% confidence intervals) for H. pylori infection among persons who consumed up to 10, 10 to 20, and more than 20 gm of alcohol per day compared with non-drinkers were 0.93 (0.77-1.13), 0.82 (0.65-1.04), and 0.71 (0.55-0.92). The inverse relation between alcohol consumption and H. pylori infection was even stronger when individuals with an indication of a recent change of alcohol consumption were excluded from the analysis, These findings support the hypothesis that moderate alcohol consumption may facilitate spontaneous elimination of H. pylori infection among adults.