Effect of iontophoretically applied 5-hydroxytryptamine on the excitability of single primary afferent C- and A-fibers in the cat spinal cord
Effect of iontophoretically applied 5-hydroxytryptamine on the excitability of single primary afferent C- and A-fibers in the cat spinal cord
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离子导入 5-羟色胺对猫脊髓中单个初级传入 C 纤维和 A 纤维兴奋性的影响
DOI：
10.1016/0006-8993(81)90218-3
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
M. Zimmermann
中科院分区：
文献类型：
--
作者：
E. Carstens;D. Klumpp;M. Randić;M. Zimmermann
本实验采用单根腓肠神经传入C、A纤维兴奋性测试，研究了5-羟色胺（5-HT）在麻醉或去大脑脊髓损伤猫脊髓内逆行激活最低阈值点的可能突触前效应。记录在腓肠神经的单纤维的阈值进行测量之前和期间的5-HT通过定位在靠近椎管内刺激电极的微量移液管的离子电渗应用。5-HT产生剂量相关的增加阈值逆向激活21或30 C-纤维。6/9的A δ-纤维和4/7的Aβ-纤维受到类似的影响。
Excitability testing of single sural afferent C- and A-fibers was employed to study possible presynaptic effects of 5-hydroxytryptamine (5-HT) applied iontophoretically at the intraspinal point of lowest threshold for their antidromic activation in anesthetized or decerebrate spinalized cats. Threshold for single fibers recorded in the sural nerve was measured prior to and during iontophoretic application of 5-HT through a micropipette positioned in close proximity to the intraspinal stimulating electrode. 5-HT produced dose-related increases in threshold for antidromic activation in 21 or 30 C-fibers. Six of 9 A δ-, and 4 of 7 Aβ-fibers were similarly affected.