[Pharmacodynamics and pharmacokinetics of remifentanil: overview and comparison with other opioids].
[Pharmacodynamics and pharmacokinetics of remifentanil: overview and comparison with other opioids].
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发表时间：
2007-11
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通讯作者：
M. Kato;D. Satoh;Yoshifumi Okada;K. Sugiyama;N. Toda;S. Kurosawa
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作者：
M. Kato;D. Satoh;Yoshifumi Okada;K. Sugiyama;N. Toda;S. Kurosawa
在这篇综述中，作者试图总结瑞芬太尼与其他阿片类药物的特点和主要差异，并概述其药效学和药代动力学。瑞芬指甲气的清除率和分布容积与其他常规阿片类药物截然不同。此外，即使连续输注瑞芬太尼超过10小时，瑞芬太尼的上下文相关半衰期也几乎稳定（约3分钟）。由于瑞芬太尼是通过非特异性酯酶代谢的，因此基本上所有接受全身麻醉和手术的患者中瑞芬太尼的排泄是可以预测的。因此，瑞芬太尼被认为是平衡全身麻醉中与吸入麻醉药或静脉催眠药联合使用的最佳阿片类镇痛药。
In this review, the authors tried to summarize the characteristics and main differences of remifentanil with other opioids, and to overview its pharmacodynamics and pharmacokinetics. Clearance and volume of distribution of remifentnail are extremely different from other conventional opioids. In addition, the context-sensitive half time of remifentanil is almost stable (about 3 minutes) even if the continuous infusion of remifentanil lasts for longer than 10 hours. As remifentanil is metabolized by a non-specific esterase, excretion of remifentnil is predictable in basically all patients undergoing general anesthesia and surgery. Therefore, remifentanil is considered to be an optimal opioid as an analgesic combined either with inhalational anesthetics or intravenous hypnotics in balanced general anesthesia.