Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study
Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study
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DOI：
10.1007/s004210000263
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发表时间：
2000-11-01
影响因子：
3
通讯作者：
Sutton, JR
中科院分区：
文献类型：
--
作者：
Crameri, RM;Weston, AR;Sutton, JR
4 名脊髓损伤患者在受伤后的前 5 个月内每周接受 5 次双腿等长电刺激训练，为期 16 周，每次 60 分钟，而 2 名 SCI 患者则未接受训练。在受伤后 1 个月内获取股外侧肌的基线活检样本，并在 16 周后获取另一份活检样本。与受伤 1 个月内采集的肌肉基线样本相比，未经训练的麻痹骨骼肌显示出以下方面的减少：(1) I 型纤维（从 50% 降至 9%），(2) 肌球蛋白重链 (MHC) I（从 27% 降至 6%），以及 (3) I 型、IIA 型和 IIX 型纤维的纤维横截面积（分别为 -62%、-68% 和 -55%）。相比之下，训练组的 I 型纤维（从 49% 到 40%）和 MHC I 组成（从 39% 到 25%）显示出较小的变化，而 I 型、IIA 型和 IIX 型纤维的纤维横截面积与基线水平相似（分别为 -3%、-8% 和 -4%）。总之，如果在受伤后立即进行电刺激训练，可以在很大程度上预防脊髓损伤对瘫痪的人体骨骼肌的不利影响。
Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was obtained within 1 month of injury, and another biopsy sample was taken after a further 16 weeks. The untrained, paralyzed skeletal muscle displayed a reduction in (1) type I fibers (from 50% to 9%), (2) myosin heavy chain (MHC) I (from 27% to 6%), and (3) fiber cross-sectional area of type I, type IIA and type IIX fibers (-62%, -68%, and -55%, respectively) when compared to the baseline sample of muscle taken within 1 month of injury. In contrast, the trained group showed smaller alterations in type I fibers (from 49% to 40%) and MHC I composition (from 39% to 25%), while fiber cross-sectional area was similar to baseline levels for type I, type IIA and type IIX fibers (-3%, -8%, and -4%, respectively). In conclusion, electrical stimulation training can largely prevent the adverse effects of a spinal cord injury upon paralyzed human skeletal muscle if applied soon after the injury.