Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown.
Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown.
复制标题
定义 anandamide 和 2-arachidonyl 甘油生物合成和分解的膜微区和代谢途径。
DOI：
10.1016/j.neuropharm.2008.07.047
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发表时间：
2008
影响因子：
4.7
通讯作者：
Barker,EricL
中科院分区：
文献类型：
--
作者：
Placzek,EkaterinaA;Okamoto,Yasuo;Ueda,Natsuo;Barker,EricL
Anandamide (AEA) 和 2-arachidonyl 甘油 (2-AG) 是 CB1 和 CB2 大麻素受体的内源性配体，被称为内源性大麻素，因为它们模仿 delta9-四氢大麻酚 (Δ9-THC)（一种植物源性大麻素）的作用。 AEA 和 2-AG 的生物合成、释放、细胞吸收和水解过程作为潜在的治疗靶点引起了人们的广泛关注。在这篇综述中，我们将讨论在表征 AEA 和 2-AG 形成和分解的主要途径方面所取得的进展，以及称为脂筏的特殊膜微域在这些过程中发挥的作用。此外，我们将回顾在生物基质中跟踪和检测 AEA 方面取得的最新进展。
Anandamide (AEA) and 2-arachidonyl glycerol (2-AG), endogenous ligands for the CB1 and CB2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the actions of delta9-tetrahydrocannabinol (Δ9-THC), a plant-derived cannabinoid. The processes by which AEA and 2-AG are biosynthesized, released, taken up by cells and hydrolyzed have been of much interest as potential therapeutic targets. In this review we will discuss the progress that has been made to characterize the primary pathways for AEA and 2-AG formation and breakdown as well as the role that specialized membrane microdomains known as lipid rafts play in these processes. Furthermore we will review the recent advances made to track and detect AEA in biological matrices.