Prediction of Boundaries Between Intrinsically Ordered and Disordered Protein Regions
Prediction of Boundaries Between Intrinsically Ordered and Disordered Protein Regions
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DOI：
10.1142/9789812776303_0021
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发表时间：
2002-12
影响因子：
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通讯作者：
P. Radivojac;Z. Obradovic;Celeste J. Brown;A. Dunker
中科院分区：
文献类型：
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作者：
P. Radivojac;Z. Obradovic;Celeste J. Brown;A. Dunker
Using proteins with both disordered and ordered regions collected through literature searches and database scanning, we assembled a set of 24-residue long segments centered on their order/disorder boundaries as well as a larger set of non-boundary segments consisting of either order or disorder. We analyzed position-specific amino acid compositions around the order/disorder boundaries and found more than thirty significant (p < 0.05) compositional differences between boundary and non-boundary data. From this analysis, we constructed several logistic regression predictors of order/disorder boundaries using slightly different data modeling approaches. Exact boundary prediction accuracies were estimated to be in the range from 74% to 80% for the different predictors.
