Chromosome 1p and 11q deletions and outcome in neuroblastoma
Chromosome 1p and 11q deletions and outcome in neuroblastoma
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DOI：
10.1056/nejmoa052399
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发表时间：
2005-11-24
影响因子：
158.5
通讯作者：
Maris, JM
中科院分区：
文献类型：
--
作者：
Attiyeh, EF;London, WB;Maris, JM
背景神经母细胞瘤是一种发病率和死亡率都很高的儿童癌症。肿瘤衍生生物标记物可能改善危险分层。方法我们对915例神经母细胞瘤样本进行了染色体1p36和11q23杂合性缺失(LOH)筛查。进一步的分析确定了11q23杂合性缺失和11q杂合性缺失的亚组病例(unb11q杂合性缺失；定义为11q丢失和11p保留)。结果898例肿瘤中有209例(23%)存在1p36位杂合性缺失，913例肿瘤中有307例(34%)11q23位杂合性缺失。307个肿瘤中有151个发现Unb11q杂合性缺失，其中11q23个杂合性缺失，占队列总数的17%。1p36LOH、11q23LOH和unb11qLOH与大多数高危疾病特征密切相关(P
BACKGROUND Neuroblastoma is a childhood cancer with considerable morbidity and mortality. Tumor-derived biomarkers may improve risk stratification.METHODS We screened 915 samples of neuroblastoma for loss of heterozygosity (LOH) at chromosome bands 1p36 and 11q23. Additional analyses identified a subgroup of cases of 11q23 LOH with unbalanced 11q LOH (unb11q LOH; defined as loss of 11q with retention of 11p). The associations of LOH with relapse and survival were determined.RESULTS LOH at 1p36 was identified in 209 of 898 tumors (23 percent) and LOH at 11q23 in 307 of 913 (34 percent). Unb11q LOH was found in 151 of 307 tumors with 11q23 LOH (17 percent of the total cohort). There was a strong association of 1p36 LOH, 11q23 LOH, and unb11q LOH with most high-risk disease features (P