Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation.
Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation.
复制标题
二氢麦角胺和去甲肾上腺素对外周循环中电阻、交换和电容功能的比较影响。
作者：
S. Mellander;I. Nordenfelt
1.在健康人和有直立症状的患者的骨骼肌和皮肤区域中进行了双氢麦角胺（DHE）和去甲肾上腺素（NA）对毛细血管前和毛细血管后阻力血管、毛细血管前“括约肌”和电容血管的作用的比较定量研究;此外，在交感神经切除前后，分析了药物在猫的肌肉、皮肤、肠和肾脏中的血管效应。2.这两种药物在皮肤血管床引起类似的反应模式，即它们都收缩阻力和电容血管，增加前/后毛细血管阻力的比例，但没有显着影响毛细血管前括约肌。NA和DHE在骨骼肌中的反应相似，但重要的例外是后者通常在肌肉阻力血管中引起中度扩张反应。3.在皮肤和肌肉中，尽管DHE对肌肉中的阻力血管没有太大影响，但DHE的电容血管的平均收缩反应显着大于NA。4. DHE对猫的肠和肾血管回路的影响相对较小。5.由于DHE的收缩作用似乎主要限于容量血管，因此该药物可能对以静脉调节受损为特征的循环障碍具有有益作用。
1. A comparative quantitative study of the effects of dihydroergotamine (DHE) and noradrenaline (NA) on the precapillary and postcapillary resistance vessels, the precapillary ‘sphincters’, and the capacitance vessels was performed in a skeletal muscle and a skin region in healthy humans and in patients with orthostatic symptoms; further, the vascular effects of the drugs were analysed in muscle, skin, intestine and kidney in cats before and after sympathectomy. 2. The two drugs evoked a similar pattern of response in the cutaneous vascular bed, i.e. they both constricted resistance and capacitance vessels, increased the ratio of pre-/post-capillary resistance, but did not significantly influence precapillary sphincters. The reactions were similar in skeletal muscle for NA and also for DHE, with the important exception that the latter drug usually elicited a moderate dilator response in the muscle resistance vessels. 3. The average constrictor responses of the capacitance vessels were significantly larger for DHE than NA in skin and also in muscle despite the fact that DHE did not much affect the resistance vessels in muscle. 4. The effects of DHE on the intestinal and renal vascular circuits in the cat were comparatively small. 5. Since the constrictor effect of DHE seems confined mainly to the capacitance vessels, the drug may have beneficial effects in circulatory disorders characterized by impaired venomotor regulation.