Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren.
Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren.
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DOI：
10.1080/0886022x.2016.1256308
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发表时间：
2017-11
期刊：
影响因子：
3
通讯作者：
Düşünsel R
中科院分区：
文献类型：
--
作者：
Dursun I;Çelik İ;Poyrazoglu HM;Köse K;Tanrıkulu E;Sahin H;Yılmaz K;Öztürk A;Yel S;Gündüz Z;Düşünsel R
目的：建立6-15岁健康儿童尿草酸盐与肌酐比值的参考值，并探讨其营养习惯与草酸盐排泄之间的关系。材料和方法：随机抽取 953 名 6-15 岁健康儿童的尿液样本，并分析草酸盐和肌酐。此外，还准备了一份 24 小时饮食回忆表并发送给他们。计算饮食的成分组成。根据年龄将儿童分为三组：第一组（69岁，n = 353人）、第二组（10-12岁，n = 335人）和第三组（13-15岁，n = 265人）。结果：6-9岁、10-12岁和13-15岁受试者草酸盐与肌酐比率的第95个百分位分别为0.048、0.042和0.042mg/mg。第1组的草酸盐与肌酐的比率显着高于第2组和第3组。尿草酸盐排泄量与蛋白质摄入量增加呈正相关，与年龄呈负相关。尿草酸盐排泄量与饮食中脯氨酸、丝氨酸、蛋白质和甘氨酸含量之间存在显着正相关。膳食脯氨酸摄入量与尿草酸盐与肌酐比值呈正相关，并且被发现是尿草酸盐的独立预测因子。结论：这些数据支持这样的观点，即每个国家都应该有自己的正常参考值来确定肾结石疾病的潜在代谢危险因素，因为蛋白质和其他营养素膳食摄入量的地区差异会影响尿中草酸盐的正常排泄。
Aim: we aimed to establish reference values for urinary oxalate to creatinine ratios in healthy children aged 6–15 years and to investigate the relationship between their nutritional habits and oxalate excretion. Materials and methods: Random urine specimens from 953 healthy children aged 6–15 years were obtained and analyzed for oxalate and creatinine. Additionally, a 24-h dietary recall form was prepared and given to them. The ingredient composition of the diet was calculated. The children were divided into three groups according to age: Group I (69 years, n = 353), Group II (10–12 years, n = 335), and Group III (13–15 years, n = 265). Results: The 95th percentile of the oxalate to creatinine ratio for subjects aged 6–9, 10–12, and 13–15 years were 0.048, 0.042, and 0.042 mg/mg, respectively. The oxalate to creatinine ratio was significantly higher in Group 1 than in Group 2 and Group 3. Urinary oxalate excretion was positively correlated with increased protein intake and negatively correlated with age. A significant positive correlation was determined between urinary oxalate excretion and the proline, serine, protein, and glycine content of diet. Dietary proline intake showed a positive correlation with the urine oxalate to creatinine ratio and was found to be an independent predictor for urinary oxalate. Conclusions: These data lend support to the idea that every country should have its own normal reference values to determine the underlying metabolic risk factor for kidney stone disease since regional variation in the dietary intake of proteins and other nutrients can affect normal urinary excretion of oxalate.