T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice.
T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice.
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DOI：
10.29245/2578-3009/2018/3.1144
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Reardon, Catherine A
中科院分区：
文献类型：
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作者：
Getz, Godfrey S;Reardon, Catherine A
动脉粥样硬化是大多数心血管疾病的潜在基础。它是一种影响动脉内膜的慢性炎症，由高胆固醇血症引起。先天免疫系统和获得性免疫系统的细胞都参与了这种炎症，巨噬细胞和T细胞是动脉粥样硬化斑块中最丰富的免疫细胞。在这篇综述中，我们讨论了T细胞和T细胞亚群在APOE-/-和LDLR-/-小鼠动脉粥样硬化模型中的作用。虽然人们普遍认为Th1细胞是促动脉粥样硬化的，调节性T细胞是动脉粥样硬化的保护性细胞，但其他亚群的作用则更加模糊。此外，在两种动脉粥样硬化模型中的结果并不总是产生相似的结果。还需要对这两种使用细胞特异性基因操作的小鼠模型进行进一步研究。
Atherosclerosis is the underlying basis for most cardiovascular diseases. It is a chronic inflammation affecting the arterial intima and is promoted by hypercholesterolemia. Cells of both the innate and adaptive immune systems contribute to this inflammation with macrophages and T cells being the most abundant immune cells in the atherosclerotic plaques. In this review, we discuss the studies that examined the role of T cells and T cell subsets in Apoe-/- and Ldlr-/- murine models of atherosclerosis. While there is a general consensus that Th1 cells are pro-atherogenic and regulatory T cells are atheroprotective, the role of other subsets is more ambiguous. In addition, the results in the two models of atherosclerosis do not always yield similar results. Additional studies in the two murine models using cell specific gene manipulations are needed.