COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals.
COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals.
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与其他黑人个体相比，患有镰状细胞病/性状的个体中的 COVID-19。
DOI：
10.1182/bloodadvances.2020003741
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发表时间：
2021-04-13
期刊：
影响因子：
7.5
通讯作者：
Panepinto JA
中科院分区：
文献类型：
--
作者：
Singh A;Brandow AM;Panepinto JA
与没有 SCD/SCT 的黑人相比，患有 SCD 的人更有可能因 COVID-19 住院、出现肺炎和疼痛。接受 SCT 的个体和未接受 SCD/SCT 的黑人个体之间的 COVID-19 结果没有显着差异。在美国，COVID-19 对黑人的影响尤为严重。镰状细胞病（SCD）和镰状细胞性状（SCT）是主要发生在黑人个体中的遗传病。与没有 SCD/SCT 的黑人相比，尚不清楚患有 SCD/SCT 的人患严重 COVID-19 疾病的风险是否更高。我们研究的目的是比较患有 SCD/SCT 的个体与没有 SCD/SCT 的黑人个体之间的 COVID-19 结局，包括疾病表现、住院和死亡。我们利用来自多站点研究网络的电子健康记录数据来识别患有 SCD/SCT 和未患有 SCD/SCT 的 COVID-19 黑人患者。在2020年1月20日至2020年9月20日的研究期间，有312名患有COVID-19和SCD的患者以及449名患有COVID-19和SCT的患者。有 45 517 名黑人被诊断患有 COVID-19，但没有 SCD/SCT。经过 1:1 倾向评分匹配（基于年龄、性别和其他既往合并症）后，COVID-19 合并 SCD 患者的住院风险（相对风险 [RR]，2.0；95% CI，1.5-2.7）以及发生肺炎（RR，2.4；95% CI，1.6-3.4）和疼痛（RR，3.4；95% CI）的风险仍然较高CI，2.5-4.8）与没有 SCD/SCT 的黑人相比。与没有 SCD/SCT 的黑人相比，患有 SCD 的黑人的病死率没有显着差异。在匹配队列中，接受 SCT 的个体和未接受 SCD/SCT 的黑人之间的 COVID-19 结果也没有显着差异。
Individuals with SCD are more likely to be hospitalized, develop pneumonia and pain due to COVID-19 than Black individuals without SCD/SCT. There are no significant differences in COVID-19 outcomes between individuals with SCT and Black individuals without SCD/SCT. In the United States, COVID-19 has disproportionately affected Black persons. Sickle cell disease (SCD) and sickle cell trait (SCT) are genetic conditions that occur predominantly among Black individuals. It is unknown if individuals with SCD/SCT are at higher risk of severe COVID-19 illness compared with Black individuals who do not have SCD/SCT. The objective of our study was to compare COVID-19 outcomes, including the disease manifestations, hospitalization, and death, among individuals with SCD/SCT vs Black individuals who do not have SCD/SCT. We leveraged electronic health record data from a multisite research network to identify Black patients with COVID-19 who have SCD/SCT and those who do not have SCD/SCT. During the study period of 20 January 2020 to 20 September 2020, there were 312 patients with COVID-19 and SCD and 449 patients with COVID-19 and SCT. There were 45 517 Black persons who were diagnosed with COVID-19 but who did not have SCD/SCT. After 1:1 propensity score matching (based on age, sex, and other preexisting comorbidities), patients with COVID-19 and SCD remained at a higher risk of hospitalization (relative risk [RR], 2.0; 95% CI, 1.5-2.7) and development of pneumonia (RR, 2.4; 95% CI, 1.6-3.4) and pain (RR, 3.4; 95% CI, 2.5-4.8) compared with Black persons without SCD/SCT. The case fatality rates for those with SCD compared with Black persons without SCD/SCT were not significantly different. There also were no significant differences in COVID-19 outcomes between individuals with SCT and Black persons without SCD/SCT within the matched cohorts.
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影响因子：
3.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
Panepinto, Julie A.;Brandow, Amanda;Schieve, Laura A.
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