Population-based biomarker screening and the development of severe preeclampsia in California
Population-based biomarker screening and the development of severe preeclampsia in California
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DOI：
10.1016/j.ajog.2014.03.026
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发表时间：
2014-10-01
影响因子：
9.8
通讯作者：
Jelliffe-Pawlowski, Laura L.
中科院分区：
文献类型：
--
作者：
Tache, Veronique;Baer, Rebecca J.;Jelliffe-Pawlowski, Laura L.
目的：本研究的目的是探讨孕中期孕妇血清生物标志物和早发性和晚发性重度子痫前期的发展之间的关系在整倍体pregnances.Study设计：包括136,139怀孕，获得孕中期产前筛查通过加州产前筛查计划与活产在2006-2008年。我们从出院记录中确定了重度先兆子痫的诊断。我们使用对数二项回归来检查异常的孕中期母体血清生物标志物和重度先兆子痫的发展之间的关联。结果：在我们的样本中，大约0.9%的所有妇女（n = 1208）经历了重度先兆子痫; 329名妇女在= 95百分位数），和低未结合雌三醇（中位数的倍数，
OBJECTIVE: The purpose of this study was to examine the relationship between second-trimester maternal serum biomarkers and the development of early-and late-onset severe preeclampsia in euploid pregnancies.STUDY DESIGN: Included were 136,139 pregnancies that obtained second-trimester prenatal screening through the California Prenatal Screening Program with live births in 2006-2008. We identified severe preeclampsia diagnoses from hospital discharge records. We used log binomial regression to examine the association between abnormal second-trimester maternal serum biomarkers and the development of severe preeclampsia.RESULTS: Approximately 0.9% of all women (n = 1208) in our sample experienced severe preeclampsia; 329 women at = 95th percentile), and low unconjugated estriol (multiple of the median,