CHEMICAL SIGNALING IN THE BRAIN
CHEMICAL SIGNALING IN THE BRAIN
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DOI：
10.1038/scientificamerican1193-58
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发表时间：
1993-11-01
影响因子：
3
通讯作者：
CHANGEUX, JP
中科院分区：
文献类型：
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作者：
CHANGEUX, JP
让-皮埃尔·尚热自1972年以来一直担任巴黎巴斯德研究所分子神经生物学部门的主任。他也是该研究所和法兰西学院的教授。Changeux因其在神经科学方面的贡献而获得了许多奖项。乙酰胆碱受体由五个亚单位组成（左），是第一个被分离出来的神经递质受体。后来的研究表明，它不仅包括神经递质结合位点，还包括离子转运通道（右）。(The为了清楚起见，β和δ亚基以及一个α亚基的一部分已经被切除。当受体处于静止状态时，通道关闭，但当两个α亚基都与乙酰胆碱联合收割机结合时，通道迅速打开。
JEAN-PIERRE CHANGEUX has been director of the molecular neurobiology unit of the Pasteur Institute in Paris since 1972. He is also a professor at the institute and at the College of France. Changeux has won many awards for his contributions to neuroscience.ACETYLCHOLINE RECEPTOR, which consists of five subunits (left), was the first neurotransmitter receptor to be isolated. Later work showed it to include not only neurotransmitter binding sites but also an ion-transporting channel (right).(The beta and delta subunits and part of one alpha subunit have been cut away for clarity.) The channel is closed when the receptor is at rest, but it opens rapidly when the two alpha subunits both combine with acetylcholine.