Influence of Immune Microenvironment on Diagnosis and Prognosis of Head and Neck Squamous Cell Carcinoma.
Influence of Immune Microenvironment on Diagnosis and Prognosis of Head and Neck Squamous Cell Carcinoma.
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免疫微环境对头颈鳞癌诊断及预后的影响
DOI：
10.3389/fonc.2021.604784
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发表时间：
2021
影响因子：
4.7
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Liu G;Yuan C;Ma J;Pan Y;Xu H
头颈部鳞状细胞癌（HNSCC）是一种免疫抑制性恶性肿瘤，伴有各种免疫细胞和细胞因子的显著改变。认识到免疫系统在促进癌症发展中的作用是我们对癌症最初理解的重要进展。我们从癌症基因组图谱（TCGA）数据库中获得了HNSCC基因表达和临床数据。我们使用通过估计RNA转录物相对子集的细胞类型鉴定（CIBERSORT）方法评估了HNSCC和邻近非癌组织中22种浸润免疫细胞类型的相对比例，确定了免疫细胞含量在肿瘤分期和生存预测中的影响。我们使用使用表达数据估计恶性肿瘤组织中的基质和免疫细胞（ESTIMATE）算法进一步预测肿瘤纯度和浸润基质/免疫细胞在HNSCC组织中的存在，鉴定其与患者存活的潜在相关性。随后通过功能富集分析和蛋白质-蛋白质相互作用（PPI）网络验证了基质和免疫评分相关的差异表达基因（DEG），并展示了它们在免疫应答中的作用。我们的研究证明了免疫微环境与HNSCC之间的潜在关联，其结果旨在为HNSCC诊断，预后和靶向免疫治疗提供有价值的术语。
Head and neck squamous cell carcinoma (HNSCC) is an immunosuppressive malignancy accompanied by noted alterations in various immune cells and cytokines. Recognition of the immune system’s role in contributing to cancer development is an important advancement in our original understanding of carcinoma. We obtained HNSCC gene expression and clinical data from The Cancer Genome Atlas (TCGA) database. We assessed the relative proportion of 22 Infiltrating immune cell types in both HNSCC and adjacent non-cancer tissues using Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method, identifying the influence of the immune cells content in tumor staging and survival prediction. We further predicted the tumor purity, and the presence of infiltrating stromal/immune cells in HNSCC tissues using Estimation of STromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithm, identifying its potential correlation with patient survival. Stromal and immune score-associated differentially expressed genes (DEGs) were subsequently verified and their roles in immune response were displayed by functional enrichment analysis and protein-protein interaction (PPI) network. Our research demonstrated the underlying association between the immune microenvironment and HNSCC, and the results were intended to serve as valuable terms for HNSCC diagnosis, prognosis, and targeted immune therapy.
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影响因子：
5.7
作者：
Lim JB;Kim DK;Chung HW
通讯作者：
Chung HW
影响因子：
4.4
作者：
Ernst, S;Lange, C;Rescher, U
通讯作者：
Rescher, U
影响因子：
6.4
作者：
Drennan, Samantha;Stafford, Nicholas D.;Green, Victoria L.
通讯作者：
Green, Victoria L.
FPR2促进胃癌细胞侵袭转移并预测患者预后
影响因子：
4.6
作者：
Hou XL;Ji CD;Tang J;Wang YX;Xiang DF;Li HQ;Liu WW;Wang JX;Yan HZ;Wang Y;Zhang P;Cui YH;Wang JM;Bian XW;Liu W
通讯作者：
Liu W
影响因子：
8.8
作者：
Mathern, Douglas R.;Horwitz, Julian K.;Heeger, Peter S.
通讯作者：
Heeger, Peter S.