The value of animal models to study immunopathology of primary human Sjögren's syndrome symptoms.
The value of animal models to study immunopathology of primary human Sjögren's syndrome symptoms.
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DOI：
10.1586/1744666x.2014.883920
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发表时间：
2014-04
影响因子：
4.4
通讯作者：
Nguyen CQ
中科院分区：
文献类型：
--
作者：
Donate A;Voigt A;Nguyen CQ
干燥综合征（SjS）是一种复杂的慢性自身免疫性疾病的多因素病因，导致最终丧失分泌功能的外分泌腺。寻找SjS的治疗性预防或治疗的挑战主要是由于缺乏对该疾病的病理生理学和临床进展的了解。为了解决这个问题，需要适当的动物模型，类似于人类SjS的主要表型，并提供一个明确的潜在的生物学或分子机制，能够定义疾病的各个方面。在这里，我们概述了SjS小鼠模型，这些模型提供了对SjS自身免疫过程的深入了解，并推进了我们对潜在诊断和治疗靶点的关注。
Sjögren’s syndrome (SjS) is a complex chronic autoimmune disease of multifactorial etiology that results in eventual loss of secretory function in the exocrine glands. The challenges towards finding a therapeutic prevention or treatment for SjS are due primarily to a lack of understanding in the pathophysiological and clinical progression of the disease. In order to circumnavigate this problem, there is a need for appropriate animal models that resemble the major phenotypes of human SjS and deliver a clear underlying biological or molecular mechanism capable of defining various aspects for the disease. Here, we present an overview of SjS mouse models that are providing insight into the autoimmune process of SjS and advance our focus on potential diagnostic and therapeutic targets.