Tumor necrosis factor-alpha in human American tegumentary leishmaniasis
Tumor necrosis factor-alpha in human American tegumentary leishmaniasis
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DOI：
10.1590/s0074-02761996000200019
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发表时间：
1996-03-01
影响因子：
2.8
通讯作者：
Coutinho, SG
中科院分区：
文献类型：
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作者：
DaCruz, AM;deOliveira, MP;Coutinho, SG
肿瘤坏死因子-α（TNF-α）是由活化的巨噬细胞和其他细胞产生的细胞因子。为了验证美国皮肤利什曼病患者血清TNF-α水平是否与疾病的治愈或加重过程相关，研究了41例患者：26例皮肤利什曼病（CL）和15例粘膜皮肤利什曼病（MCL）。在活动性疾病期间，MCL患者的血清TNF-α水平显著高于CL患者和对照受试者（健康个体和来自其他病因的皮肤病变）。MCL患者在锑治疗结束时血清TNF-α滴度显著低于治疗前。6个月随访后，MCL患者的血清TNF-α水平与治疗结束时观察到的水平以及CL患者和对照受试者的血清TNF-α水平相似。在整个研究期间（治疗前、治疗结束时和6个月随访后），CL患者的血清TNF-α水平无显著变化。高TNF-α血清水平和疾病的严重程度之间的可能关系进行了讨论。
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by activated macrophages and other cells. In order to verify whether the serum levels of TNF-alpha in American tegumentary leishmaniasis patients are associated with the process of cure or aggravation of the disease, 41 patients were studied: 26 cases of cutaneous leishmaniasis (CL) and 15 of mucocutaneous leishmaniasis (MCL). During active disease the serum levels of TNF-alpha of MCL patients were significantly higher than those of CL patients and control subjects (healthy individuals and cutaneous lesions from other etiologies). The MCL patients had serum titers of TNF-alpha significantly lower at the end of antimonial therapy than before therapy After a six-month follow-up, the MCL patients had serum levels of TNF-alpha similar to those observed at the end of the therapy as well as to those of CL patients and control subjects. No significant variation in the serum levels of TNF-alpha was observed in CL patients throughout the study period (before, at the end of therapy and after a six-month follow-up). The possible relationship between the high TNF-alpha serum levels and severity of the disease is discussed.