A decision analysis: The dental management of patients prior to hematology cytotoxic therapy or hematopoietic stem cell transplantation
A decision analysis: The dental management of patients prior to hematology cytotoxic therapy or hematopoietic stem cell transplantation
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DOI：
10.1016/j.oraloncology.2006.12.006
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发表时间：
2008-01-01
期刊：
影响因子：
4.8
通讯作者：
Meyerowitz, Cyril
中科院分区：
文献类型：
--
作者：
Elad, Sharon;Thierer, Todd;Meyerowitz, Cyril
有争议的是，牙齿。在化疗方案（包括造血干细胞移植（HSCT））之前的治疗有助于在随后的免疫抑制期间预防感染。本研究的目的是开发一个决策分析框架，以测试化疗前牙科治疗对患者生存的影响。创建了一个决策树，以比较接受细胞毒性药物或接受HSCT的基础病例患者的两种治疗方案的临床结局。用于建立模型的变量为"全身感染"、"未满足的牙科需求"、"牙科需求"。比较两种策略的结局评价是“生存”。我们进行了MEDLINE和PubMed检索的英语文献，根据相关术语的列表。决策分析模型选择牙科治疗化疗前作为基础病例分析的首选策略。这项研究的结果表明，化疗前的牙科治疗是首选的治疗策略。使用我们的基础病例数据，与化疗策略前未治疗的患者相比，每1000例血液肿瘤患者或HSCT患者中有1.8例死亡。(c)2006爱思唯尔有限公司版权所有。
There is a controversy regarding whether dental. treatment before chemotherapy protocols, including hematopoietic stem cell transplantation (HSCT), is helpful to prevent infections during the consequent immunosuppression. The aim of this study was to develop a decision analysis framework that would test the effect of dental treatment prior to chemotherapy on the survival of the patient. A decision tree was created to compare the clinical outcomes of two treatment alternatives for a base-case patient receiving cytotoxics or undergoing HSCT. The variables used to build the model were "systemic infection", "unmet dental needs", "dental needs". The outcomes evaluate to compare the two strategies was "survival". We performed MEDLINE and PubMed searches of English-language literature according to a list of related terms. The decision analysis model selected dental treatment prior to chemotherapy as the preferred strategy for the base case analysis. The results of this study suggest that dental treatment prior to chemotherapy is the preferred treatment strategy. Using our base case data, 1.8 of every 1000 hemato-oncologic patients or HSCT patients will die compared to the non-treatment prior to chemotherapy strategy. (c) 2006 Elsevier Ltd. All rights reserved.