Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
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DOI：
10.1111/j.1872-034x.2010.00747.x
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Suzuki, Kazuyuki
中科院分区：
文献类型：
--
作者：
Wang, Ting;Takikawa, Yasuhiro;Suzuki, Kazuyuki
目的：鼠尾草酸（CA）在体外抑制脂肪形成。本研究评估了CA对ob/ob小鼠的治疗效果。方法：实验动物给予含或不含CA的标准饲料5周。在此期间测量体重增加和食物摄入量。进行磁共振成像分析、组织学检查、血清化学分析和腹膜内葡萄糖耐量试验（IPGTT）。结果：喂食CA的小鼠体重明显减轻，内脏脂肪减少，血清甘油三酯（TG）和胆固醇水平也显着降低。重要的是，CA 通过降低肝脏 TG 含量，从而降低血清丙氨酸氨基转移酶水平，对肝脏产生显着影响。此外，IPGTT显示CA显着改善了葡萄糖耐量。结论：这些数据表明CA是肥胖相关非酒精性脂肪肝的新型治疗剂。
Aim:Carnosic acid (CA) inhibits adipogenesis in vitro. The present study evaluated the therapeutic effects of CA in ob/ob mice.Methods:The experimental animals were given a standard chow diet with or without CA for 5 weeks. Bodyweight gain and food intake were measured during this period. Magnetic resonance imaging analysis, histological examination, serum chemistry analysis and intraperitoneal glucose tolerance test (IPGTT) were all performed.Results:The mice fed CA experienced significant weight loss and reduced visceral adiposity, in addition to significantly reduced serum triglyceride (TG) and cholesterol levels. Importantly, CA had a dramatic effect on the liver by reducing the hepatic TG content, thus decreasing serum alanine aminotransferase levels. In addition, IPGTT revealed that CA significantly improved glucose tolerance.Conclusion:These data suggest that CA is a novel therapeutic agent for obesity-related non-alcoholic fatty liver disease.