Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats.
Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats.
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DOI：
10.18632/oncotarget.20779
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发表时间：
2017-09-26
期刊：
影响因子：
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通讯作者：
Lin Z
中科院分区：
文献类型：
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作者：
Fang M;Jiang H;Ye L;Cai C;Hu Y;Pan S;Li P;Xiao J;Lin Z
新生儿缺氧缺血性脑损伤是一种毁灭性疾病，常导致死亡和有害的神经功能缺损。本研究旨在评估二甲双胍在新生儿缺氧缺血性脑损伤模型中提供神经保护的能力，并研究这些保护作用背后的相关分子机制。在这里，我们发现二甲双胍治疗显著减少HI损伤后24小时的脑梗死体积和脑水肿，二甲双胍的神经保护作用与抑制神经元凋亡、抑制神经炎症和改善血脑屏障破坏有关。此外，二甲双胍治疗在HI损伤后7天对脑损伤具有长期保护作用。我们的研究表明，二甲双胍治疗可以预防新生儿缺氧缺血性脑损伤，因此有可能作为一种治疗这种疾病的方法。
Neonatal hypoxic-ischemic (HI) brain injury is a devastating disease that often leads to death and detrimental neurological deficits. The present study was designed to evaluate the ability of metformin to provide neuroprotection in a model of neonatal hypoxic-ischemic brain injury and to study the associated molecular mechanisms behind these protective effects. Here, we found that metformin treatment remarkably attenuated brain infarct volumes and brain edema at 24 h after HI injury, and the neuroprotection of metformin was associated with inhibition of neuronal apoptosis, suppression of the neuroinflammation and amelioration of the blood brain barrier breakdown. Additionally, metformin treatment conferred long-term protective against brain damage at 7 d after HI injury. Our study indicates that metformin treatment protects against neonatal hypoxic-ischemic brain injury and thus has potential as a therapy for this disease.