Parental hypertension and cardiovascular response to cognitive and isometric challenge.
Parental hypertension and cardiovascular response to cognitive and isometric challenge.
复制标题
父母高血压和心血管对认知和等长挑战的反应。
DOI：
10.1111/j.1469-8986.1982.tb02571.x
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发表时间：
1982
期刊：
影响因子：
3.7
通讯作者：
Proietti,JM
中科院分区：
文献类型：
--
作者：
Manuck,SB;Proietti,JM
这项调查的目的是比较高血压和正常血压父母的儿子对涉及认知和等长挑战的任务的心血管反应，并检查心率（HR）反应性的个体差异与基线血压（BP）测量的关系。 36 名男性本科生志愿者（18 名有高血压父母史，18 名没有高血压父母史）被安排进行两次 1 小时的实验（第一天和第二天）。第一天，在受试者执行三项实验室任务中的每一项时获得心率和血压测量值：概念形成的困难测试、连续减法以及以最大自主收缩的 30% 持续握力。每项任务持续 3 分钟，之前有 3 分钟的基线间隔。第二天，受试者被要求安静地放松，同时记录心率和血压的基线测量值。与血压正常的父母的儿子相比，高血压患者的后代在所有任务期间都表现出更高的平均收缩压。在第一天或第二天基线记录中没有观察到相应的组间差异。与收缩压不同，舒张压测量值不会因父母高血压/正常血压状态而发生可靠变化。尽管高血压患者的儿子的平均 HR 显着高于血压正常的后代，但这些差异在基线和任务间隔上都是一致的。在两项认知任务期间被确定为高 HR 反应者的受试者中，高血压父母的儿子表现出的第 2 天基线收缩压比没有父母高血压病史的受试者高约 9 mmHg。在被确定为低心率反应者的受试者中，高血压和正常血压父母的儿子之间的基线收缩压没有可靠的差异。
The purposes of this investigation were to contrast the cardiovascular responses of sons of hypertensive and normotensive parents to tasks involving cognitive and isometric challenge, and lo examine the relationship of individual differences in heart rate (HR) reactivity to baseline blood pressure (BP) measurements. Thirty‐six male, undergraduate volunteers (18 with and 18 without a parental history of hypertension) were scheduled for two, 1‐hr experimental sessions (Days I and II). On Day 1, HR and BP measurements were obtained while subjects performed each of three laboratory tasks: a difficult test in concept formation, serial subtraction, and a sustained handgrip at 30% of maximum voluntary contraction. Each task lasted 3 min and was preceded by a 3‐min baseline interval. On Day II, subjects were instructed to relax quietly while baseline measures of HR and BP were recorded. Relative to sons of normotensive parents, offspring of hypertensives exhibited higher mean Systolic BPs during all task periods; no corresponding group differences were observed on either Day I or Day II baseline recordings. Unlike SBP, Diastolic BP measurements did not vary reliably by parental hypertensive/normotensive status. Although the mean HRs of sons of hypertensives were significantly higher than in offspring of normotensives, these differences obtained uniformly across both the baseline and task intervals. Among subjects identified as High HR reactors during the two cognitive tasks, sons of hypertensive parents exhibited Day II baseline SBPs about 9 mmHg higher than did subjects without a parental history of hypertension. Among subjects identified as Low HR reactors, baseline SBPs did not differ reliably between sons of hypertensive and normotensive parents.