Increased levels of interleukin-10 in saliva of Sjogrens's syndrome patients. Correlation with disease activity
Increased levels of interleukin-10 in saliva of Sjogrens's syndrome patients. Correlation with disease activity
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DOI：
10.1007/s10238-004-0049-9
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发表时间：
2004-04-01
影响因子：
4.6
通讯作者：
Cordone, G
中科院分区：
文献类型：
--
作者：
Bertorello, R;Cordone, MP;Cordone, G
本研究的目的是测定干燥综合征患者唾液中IL-10、IL-2、IL-4和干扰素-γ的水平，并探讨其与疾病活动性的实验室和临床指标之间的关系。采用双抗体夹心法测定14例干燥综合征患者和26例健康人唾液标本中IL-2、IL-4、IL-10和干扰素-γ水平。干燥综合征患者唾液中IL-10水平明显高于正常对照组(P=0.007)。干扰素升高。在一些患者中发现了这种水平。在所有唾液样本中均未检测到IL-2和IL-4。在患者中，IL-10水平与干眼症、口干症的严重程度及血沉呈显著正相关(P=0.006)。我们的数据表明，在干燥综合征患者的唾液中可以检测到IL-10水平的升高，并与疾病的严重程度相关。
The aim of the study was to determine the levels of interleukin (IL)-10, IL-2, IL-4, and interferon-gamma in the saliva of patients with Sjogren's syndrome and to correlate them with laboratory and clinical parameters of disease activity. The levels of IL-2, IL- 4, IL-10, and interferon-gamma were measured in salivary samples, obtained directly from the Stenone duct of 14 Sjogren's syndrome patients and 26 healthy controls by ELISA. A significant elevation of IL- 10 was found in salivary fluids of Sjogren's syndrome patients compared with healthy controls ( P = 0.007). Elevated interferon. levels were found in some patients. IL-2 and IL-4 were undetectable in all saliva samples. In patients, IL-10 levels significantly correlated with the degree of xerophthalmia and xerostomia ( P = 0.02 and P = 0.01, respectively) and with the erythrocyte sedimentation rate ( P = 0.006). Our data suggest that elevated IL-10 levels are detectable in the saliva of Sjogren's syndrome patients and correlate with the severity of the disease.