Expression of contact, a new zebrafish DVR member, marks mesenchymal cell lineages in the developing pectoral fins and head and is regulated by retinoic acid
Expression of contact, a new zebrafish DVR member, marks mesenchymal cell lineages in the developing pectoral fins and head and is regulated by retinoic acid
复制标题
DOI：
10.1016/s0925-4773(97)00072-5
复制
发表时间：
1997-07-01
影响因子：
2.6
通讯作者：
Rosa, FM
中科院分区：
文献类型：
--
作者：
Bruneau, S;Mourrain, P;Rosa, FM
接触，一个新的斑马鱼转化生长因子-β（TGF-β）的成员是最密切相关的小鼠GDF 5和人类CCR 4 -1负责，突变时，肢体短足症表型和亨特-汤普森综合征，分别。接触表现出一个动态的空间表达模式，在咽弓和胸鳍芽，更预示着软骨形成。在鳍芽内，在近端间充质中检测到接触表达，内骨骼将从中发育。外源性应用视黄酸（RA）诱导复制的胸鳍雏形在斑马鱼胚胎以及接触表达沿着近端边缘的鳍间充质显示，内骨骼和外骨骼可以复制。(C)1997 Elsevier Science爱尔兰有限公司
Contact, a new zebrafish transforming growth factor-beta (TGF-beta) member is most closely related to mouse GDF5 and to human CDMP-1 responsible, when mutated, for limb brachypodism phenotype and Hunter-Thompson syndrome, respectively. Contact exhibits a dynamic spatial expression pattern in the pharyngeal arches and the pectoral fin buds that much prefigures cartilage formation. Within the fin buds, contact expression is detected in the proximal mesenchyme from which the endoskeleton will develop. Exogeneously applied retinoic acid (RA) induces duplication of the pectoral fin rudiment in zebrafish embryos as well as contact expression along the proximal margin of the fin mesenchyme showing that both endoskeleton and exoskeleton can be duplicated. (C) 1997 Elsevier Science Ireland Ltd.