CHANGES OF ACTION POTENTIAL SHAPE AND VELOCITY FOR CHANGING CORE CONDUCTOR GEOMETRY
CHANGES OF ACTION POTENTIAL SHAPE AND VELOCITY FOR CHANGING CORE CONDUCTOR GEOMETRY
复制标题
DOI：
10.1016/s0006-3495(74)85947-3
复制
发表时间：
1974-01-01
影响因子：
3.4
通讯作者：
RALL, W
中科院分区：
文献类型：
--
作者：
GOLDSTEIN, SS;RALL, W
在改变核心导体几何形状的区域中计算动作电位的形状和速度的理论变化。研究了直径的阶跃减小和阶跃增加、分支点以及直径的逐渐变细或变宽。结果表明，当动作电位接近阶跃下降点时，速度和峰高均增加。一个步骤的增加会导致速度和峰值高度的减少与方法;传播可能失败，成功与短暂的延迟，或，与较长的延迟，成功在向前和向后的方向。当d3/2值匹配时，分支的形状和无量纲速度τθ/λ保持不变。如果没有这种匹配，动作电位的形状和无量纲速度的变化对应于直径的阶跃减小或阶跃增加。对于耀斑或锥形区域，发现（对于先前定义的特定类别）速度与变化的长度常数成比例变化。发现了一个简单的公式来预测这个比例常数如何取决于耀斑或锥度的量。
The theoretical changes in shape and velocity of an action potential were computed in regions of changing core conductor geometry. Step decrease and step increase of diameter, branch points, and gradual taper or flare of diameter were studied. Results showed increase of both velocity and peak height as the action potential approaches a point of step decrease. A step increase causes decrease of both velocity and peak height with approach; propagation may either fail, succeed with brief delay, or, with longer delay, succeed in both forward and reverse directions. With branching, both the shape and the dimensionless velocity, τθ/λ, remain unchanged when the d3/2values are matched. Without such matching, the changes of shape and dimensionless velocity of an action potential correspond to those found for step decrease or step increase of diameter. For regions of flare or taper, it was found (for a specific previously defined class) that velocity changed in proportion with the changing length constant. A simple formula was found to predict how this proportionality constant depends upon the amount of flare or taper.