Melatonin might be one possible medium of electroacupuncture anti-seizures
Melatonin might be one possible medium of electroacupuncture anti-seizures
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DOI：
10.3727/036012901816356027
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发表时间：
2001-01-01
影响因子：
0.3
通讯作者：
Cheng, JS
中科院分区：
文献类型：
--
作者：
Chao, DM;Chen, G;Cheng, JS
为探讨癫痫发作和电针抗癫痫发作时松果体、海马区和血清中褪黑激素(MT)水平的变化，我们采用海马区微量注射青霉素的方法建立了大鼠癫痫发作模型。电针大鼠“风谷穴”和“金锁穴”。记录大鼠脑电，分析与脑电30 HZ频段相近的1个频段的相对功率(Rp)。采用毛细管电泳法测定MT含量。结果表明，癫痫发作急性期松果体和海马区MT水平明显升高，血清MT水平先无明显变化，然后显著升高。电针30min可显著增强MT水平的升高(P
To explore the alteration of melatonin (MT) levels in pineal, hippocampus and serum during seizure crises and electroacupuncture (EA) anti-seizures, we established a rat seizure model bymicroinjecting benzylpenicillin into hippocampus. EA was performed on "Fengu" (DU 16) and "Jinsuo" (DU 8) acupoints in rats. Electroencephalogram (EEG) of rats was recorded and the relative power (RP) of 1 similar to 30 HZ band of EEG was analyzed. A capillary electrophoresis-electrochemical detection method was used to determine MT contents. Our results indicated that MT level was elevated in pineal and hippocampus, and first had no change then significantly evaluated in serum during seizure crisis. The elevation of MT level was greatly potentiated with 30 min EA treatment (P