Use of antidepressants and rates of hip bone loss in older women
Use of antidepressants and rates of hip bone loss in older women
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DOI：
10.1001/archinte.167.12.1240
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发表时间：
2007-06-25
影响因子：
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通讯作者：
Ensrud, Kristine E.
中科院分区：
文献类型：
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作者：
Diem, Susan J.;Blackwell, Terri L.;Ensrud, Kristine E.
背景：5-羟色胺转运体最近被描述在骨骼中，这增加了阻止5-羟色胺再摄取的药物可能影响骨代谢的可能性。方法：我们评估了选择性5-羟色胺再摄取抑制剂(SSRIs)和三环抗抑郁药(TCAs)的当前使用情况，并获得了2722名老年妇女(平均年龄78.5岁)参与骨质疏松性骨折研究的连续骨密度(BMD)测量，这是一项针对社区女性的前瞻性队列研究。髋部骨密度在第六次检查时测量，平均4.9年后在第八次检查中测量。我们将女性归类为非使用者(在两次检查中没有使用SSRI或TCA；n=2406)，SSRI使用者(在两次检查中使用SSRI，但没有TCA；n=198)，或TCA使用者(在两次检查中使用TCA，但没有SSRI；n=118)。结果：在调整了包括老年抑郁量表评分在内的潜在混杂因素后，未使用SSRI的患者的髋部骨密度平均每年下降0.47%，而使用SSRI的患者平均每年下降0.82%(P
Background: Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism.Methods: We assessed current use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) and obtained serial bone mineral density (BMD) measurements in a cohort of 2722 older women (mean age, 78.5 years) participating in the Study of Osteoporotic Fractures, a prospective cohort study of community-dwelling women. Hip BMD was measured at the sixth examination and an average of 4.9 years later at the eighth examination. We categorized women as nonusers (used no SSRIs or TCAs at either examination; n= 2406), SSRI users (used SSRIs but no TCAs at either examination; n= 198), or TCA users (used TCAs but no SSRIs at either examination; n= 118). Depressive symptoms were identified using a cutoff score of at least 6 on the Geriatric Depression Scale.Results: After adjustment for potential confounders, including the Geriatric Depression Scale score, mean total hip BMD decreased 0.47% per year in nonusers compared with 0.82% in SSRI users (P