Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates.
Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates.
复制标题
来感受气氛，留下来感受相互作用：破译小分子分解成生物分子凝聚物的过程。
DOI：
10.1016/j.chembiol.2023.10.015
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发表时间：
2023
影响因子：
8.6
通讯作者：
Villegas,JoséA
中科院分区：
文献类型：
--
作者：
Sepehri,Bakhtyar;Drew,Kevin;Villegas,JoséA
优化药代动力学性质仍然具有挑战性，但通常由一套结构规则指导。然而，细胞内分布没有这样的规则集。Kilgore等人研究了生物分子凝聚物中的小分子分配，其发现可能为药物设计和发现过程打开一扇新的窗口。
Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for intracellular distribution. Kilgore et al.1have examined small molecule partitioning within biomolecular condensates, yielding findings that could open a new window in the drug design and discovery process.