Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens
Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens
复制标题
DOI：
10.1385/ir:27:2-3:149
复制
发表时间：
2003-01-01
影响因子：
4.4
通讯作者：
Caspi, RR
中科院分区：
文献类型：
--
作者：
Caspi, RR
我们的兴趣围绕着调节自身耐受性的生物学机制的研究，免疫特权视网膜蛋白作为目标，在视力威胁自身免疫性葡萄膜炎疾病。这些研究旨在了解对这些抗原的自身耐受性如何在个体发育过程中发展并在成年期维持，其病理学分解所涉及的过程，带来缓解和恢复的调节机制，以及最后，我们如何利用这些过程的知识进行耐受性的治疗性恢复。为了回答这些问题，我们在大鼠和小鼠中使用实验性自身免疫性葡萄膜炎（EAU）模型。由于潜在的免疫学机制的共性，在实验性眼部模型中学到的经验教训和概念适用于其他疾病实体，并且相反，从其他自身免疫性疾病收集的数据适用于葡萄膜炎的研究。
Our interests revolve around the study of biological mechanisms regulating self-tolerance to immunologically privileged retinal proteins that serve as targets in sight-threatening autoimmune uveitic disease. These studies are aimed at understanding how self-tolerance to these antigens develops during ontogeny and is maintained during adulthood, the processes involved in its pathological breakdown, the regulatory mechanisms that bring about remission and recovery, and, finally, how we can utilize knowledge of these processes for therapeutic restoration of tolerance. To answer these questions, we use the experimental autoimmune uveitis (EAU) model in rats and mice. Because of the commonality of underlying immunological mechanisms, lessons and concepts learned in experimental ocular models are applicable to other disease entities, and, conversely, data gleaned from other autoimmune diseases are applicable to the study of uveitis.