Salmonella interactions with host cells:: in vitro to in vivo
Salmonella interactions with host cells:: in vitro to in vivo
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DOI：
10.1098/rstb.2000.0603
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发表时间：
2000-05-29
期刊：
影响因子：
--
通讯作者：
Brumell, JH
中科院分区：
文献类型：
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作者：
Finlay, BB;Brumell, JH
沙门氏菌病（由沙门氏菌引起的疾病）有几种临床表现，从胃肠炎（食物中毒）到伤寒（肠）热和菌血症。沙门氏菌种类（尤其是鼠伤寒沙门氏菌）也代表了一种有机体，可以很容易地用于研究病原体与其宿主之间发生的复杂相互作用，无论是在体外还是在体内。鼠伤寒沙门氏菌易于培养和遗传操作，再加上组织培养模型和动物模型的可用性，使得鼠伤寒沙门氏菌成为此类研究的理想生物。在这篇综述中，我们重点关注沙门氏菌与宿主细胞的相互作用，包括组织培养（体外）和相关动物模型（体内），并比较使用这些不同模型获得的结果。最近复杂的成像和分子遗传工具的出现促进了对发生的事件的研究。在疾病中，从而确认组织培养结果，同时确定在相关疾病环境中需要解决的新问题。
Salmonellosis (diseases caused by Salmonella species) have several clinical manifestations, ranging from gastroenteritis (food poisoning) to typhoid (enteric) fever and bacteraemia. Salmonella species (especially Salmonella typhimurium) also represent organisms that call be readily used to investigate the complex interplay that occurs between a pathogen and its host, both in vitro and in vivo. The ease with which S. typhimurium can be cultivated and genetically manipulated, in combination with the availability of tissue culture models and animal models, has made S. typhimurium a desirable organism for such studies. In this review, we focus on Salmonella interactions with its host cells, both in tissue culture (in vitro) and in relevant animal models (in vivo), and compare results obtained using these different models. The recent advent of sophisticated imaging and molecular genetic tools has facilitated studying the events that occur. in disease, thereby confirming tissue culture results, yet identifying new questions that need to be addressed in relevant disease settings.