The effect of the ingestion of ethanol on obstruction of the left ventricular outflow tract in hypertrophic cardiomyopathy
The effect of the ingestion of ethanol on obstruction of the left ventricular outflow tract in hypertrophic cardiomyopathy
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DOI：
10.1056/nejm199609263351305
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发表时间：
1996-09-26
影响因子：
158.5
通讯作者：
Kronzon, I
中科院分区：
文献类型：
--
作者：
Paz, R;Jortner, R;Kronzon, I
背景乙醇会导致血管舒张，这可能会因左心室流出道阻塞增加而对肥厚型梗阻性心肌病患者产生不利影响。我们评估了肥厚型心肌病患者摄入社会常用量的乙醇对血流动力学的影响。方法我们对 36 名患者在摄入 50 毫升 40% 乙醇或具有朗姆酒香气的等热量安慰剂之前和之后多次进行了超声心动图检查。每个患者在不同的日子接受乙醇和安慰剂。患者（而非医生）对饮料的成分一无所知。我们测量了左心房和左心室的大小、左心室壁厚度、血压、心率、二尖瓣收缩期前移程度以及左心室流出道压力梯度。结果摄入乙醇导致平均 (+/-SD) 收缩压显着下降（从 130.5+/-18.6 至 122.5+/-20.3 mm Hg，P
Background Ethanol causes vasodilatation, which might have an adverse effect, due to increased obstruction of the left ventricular outflow tract, in patients with hypertrophic obstructive cardiomyopathy. We assessed the hemodynamic effects of the ingestion of ethanol, in an amount commonly consumed socially, in patients with hypertrophic cardiomyopathy.Methods We performed echocardiography in 36 patients before and several times after the ingestion of either 50 ml of 40 percent ethanol or an isocaloric placebo with the aroma of rum. Each patient received both ethanol and placebo, on different days. The patients, but not the physicians, were blinded to the content of the drink. We measured the sizes of the left atrium and left ventricle, the left-ventricular-wall thickness, blood pressure, heart rate, the degree of systolic anterior motion of the mitral valve, and the pressure gradient across the left ventricular outflow tract.Results The ingestion of ethanol resulted in a significant drop in the mean (+/-SD) systolic blood pressure (from 130.5+/-18.6 to 122.5+/-20.3 mm Hg, P