Plasma prolactin level and risk of incident hypertension in postmenopausal women.
Plasma prolactin level and risk of incident hypertension in postmenopausal women.
复制标题
绝经后妇女的血浆催乳素水平和高血压发生风险。
DOI：
10.1097/hjh.0b013e328339f254
复制
发表时间：
2010
影响因子：
4.9
通讯作者：
Forman,JohnP
中科院分区：
文献类型：
--
作者：
Zhang,Luxia;Curhan,GaryC;Forman,JohnP
BackgroundLaboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported.MethodsWe prospectively examined the association between daytime plasma prolactin levels and the risk of incident hypertension among 874 postmenopausal women who were participants of the Nurses' Health Study. Cox proportional hazards regression models were used to adjust for potential confounders.ResultsWe identified 183 incident cases of hypertension during 8 years of follow-up. After adjusting for potential confounders, the relative risk of hypertension for a 1-standard deviation higher plasma prolactin was 1.31 (95% confidence interval 1.05–1.62). Compared with women with plasma prolactin levels of 8.0 ng/ml or below, the multivariable relative risk of incident hypertension for those with prolactin levels above 8.0 ng/ml was 1.34 (95% confidence interval 0.90–1.99).ConclusionA higher daytime plasma prolactin level is independently associated with an increased risk of incident hypertension among postmenopausal women.
