Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols.
Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols.
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4-取代的山奈-3-醇的合成和生物学评价。
DOI：
10.1021/acs.joc.9b03461
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
O'Doherty,GeorgeA
中科院分区：
文献类型：
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作者：
Kim,Sugyeom;Li,Yu;Lin,Lin;Sayasith,PeytonR;Tarr,ArielT;Wright,EricB;Yasmin,Sharia;Lannigan,DeborahA;O'Doherty,GeorgeA
介绍了两个系列五种山奈酚的合成方法。第一组都有一个C-3羟基，第二组在C-3位有一个羧基甲氧基醚。这两个系列在C-4′位置都有可变取代（即，OH、Cl、F、H、OMe）。山奈酚和羧甲氧基醚均被评价其抑制核糖体S6激酶（RSK）活性和癌细胞增殖的能力。
The synthesis of two series of five kaempfer-3-ols was described. The first set all have aC-3 hydroxyl group and the second has a carboxymethoxy ether at theC-3 position. Both series have variable substitution at theC-4′ position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.