Elevation of plateletcrit increasing the risk of non-alcoholic fatty liver disease development in female adults: A large population-based study
Elevation of plateletcrit increasing the risk of non-alcoholic fatty liver disease development in female adults: A large population-based study
复制标题
血小板压积升高会增加成年女性患非酒精性脂肪肝的风险：一项基于大规模人群的研究
DOI：
10.1016/j.cca.2017.08.031
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发表时间：
2017
影响因子：
5
通讯作者：
Zheng Ming-Hua
中科院分区：
文献类型：
--
作者：
Wang Li-Ren;Zhou Yi-Fan;Zhou Yu-Jie;Zhang Shu-Hao;Liu Wen-Yue;Wu Sheng-Jie;Van Poucke Sven;Zheng Ming-Hua
背景非酒精性脂肪性肝病（NAFLD）是中国最常见的慢性肝病之一，因此应用生物标志物预测NAFLD的发展具有重要意义。目的本研究旨在评估中国女性成人血小板压积（PCT）与非酒精性脂肪性肝病（NAFLD）之间的关联。方法本研究根据超声定义NAFLD，并对温州人民医院9737名无NAFLD的女性受试者进行随访。平均研究时间为五年。 NAFLD PCT 四分位数（Q1 至 Q4）的确定定义为：0–0.16、0.17–0.18、0.19–0.21、≥ 0.22。以 Q1 为参考，计算每个四分位数不同模型中的 95% 置信区间 (CI) 和风险比 (HR)。 结果从 Q1 到 Q4，发生率 (95% CI) 分别为 8.30 (7.14–9.47)、11.51 (10.12–12.89)、12.68 (11.47–13.89) 和16.46（15.03–17.88）。仅考虑 PCT，在纵向人群中，与 Q1 相比，Q2、Q3 和 Q4 的 HR 值（95% CI）分别为 1.51 (1.25–1.84)、1.72 (1.44–2.06) 和 2.34 (1.96–2.79)。调整所有已知的混杂变量后，与 Q1 相比，Q2、Q3 和 Q4 中女性的 HR (95% CI) 分别为 1.31 (1.08–1.60)、1.30 (1.09–1.56) 和 1.54 (1.29–1.84)。结论我们报道，血清 PCT 水平升高被认为是女性 NAFLD 发展的独立显着预测因子。高PCT水平有助于NAFLD的发展。
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the one of the most common form of chronic liver disease in China, so it is important to apply bio-marker in predict the development of NAFLD.AimsThis study aims to evaluate association between plateletcrit (PCT) and non-alcoholic fatty liver disease (NAFLD) in Chinese female adults.MethodsNAFLD was defined as per ultrasound in this study and 9737 NAFLD-free female subjects from Wenzhou People's Hospital were followed for five years in average in the study. The determination of NAFLD PCT quartiles (Q1 to Q4) were defined: 0–0.16, 0.17–0.18, 0.19–0.21, ≥ 0.22. With Q1 used as reference, 95% confidence intervals (CIs) and hazard ratios (HRs) in different models were computed across each quartile.ResultsFrom Q1 to Q4, the incidence ratios (95% CIs) were 8.30 (7.14–9.47), 11.51 (10.12–12.89), 12.68 (11.47–13.89) and 16.46 (15.03–17.88). Simply considering PCT, in the longitudinal population, values in Q2, Q3 and Q4 had HRs (95% CIs) are 1.51 (1.25–1.84), 1.72 (1.44–2.06) and 2.34 (1.96–2.79) versus Q1. After adjusting for all known confounding variables, values in Q2, Q3 and Q4 had HRs (95% CIs) of 1.31 (1.08–1.60), 1.30 (1.09–1.56) and 1.54 (1.29–1.84) in females compared with Q1.ConclusionsWe reported that elevated serum PCT levels are considered as an independently significant predictor for NAFLD development in females. The high PCT level contributes to the development of NAFLD.