SERUM CHOLESTEROL RESPONSE TO CHANGES IN DIET .4. PARTICULAR SATURATED FATTY ACIDS IN DIET
SERUM CHOLESTEROL RESPONSE TO CHANGES IN DIET .4. PARTICULAR SATURATED FATTY ACIDS IN DIET
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DOI：
10.1016/0026-0495(65)90004-1
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发表时间：
1965-01-01
期刊：
影响因子：
9.8
通讯作者：
GRANDE, F
中科院分区：
文献类型：
--
作者：
KEYS, A;ANDERSON, JT;GRANDE, F
对于许多饮食变化，[DELTA] Chol给出了以mg/100 ml为单位的人血清胆固醇水平平均变化的令人满意的预测。= 1。35 (2[δ] s - [δ] p) + 1。5[DELTA]Z其中S和P是饮食中饱和脂肪酸和多不饱和脂肪酸的甘油酯提供的总热量的百分比Z2 =毫克膳食胆固醇/1000卡路里。然而，当饮食变化涉及大量可可脂时，这个公式就失效了，并且与牛油或氢化椰子油饮食也出现差异。明尼苏达大学（University of Minnesota）和另外两个研究中心进行的对照饮食实验，提供了63组男性的血清胆固醇平均值对比，每组男性采用两种具有化学特征的饮食。最小二乘分析表明，硬脂酸以及含有少于12个碳原子的饱和脂肪酸对人体血清胆固醇的影响很小或没有影响。方程，[DELTA] Chol。= 1。2(2[DELTA]S[image] - AP) + 15[DELTA]Z，与这63组数据的观测值具有良好的相关性（r = 0.93）。这种表述也解决了迄今为止在文献中令人困惑的差异。
For many dietary changes satisfactory prediction of the average change in the serum cholesterol level of man in mg/100 ml, is given by [DELTA] Chol. = 1. 35 (2[DELTA]S - [DELTA]P) + 1. 5[DELTA]Z where S and P are percentages of total calories provided by glycerides of saturated and polyunsaturated fatty acids in the diet and Z2 = mg. of dietary cholesterol/1000 Cal. This formula fails, however, when the dietary change involves large amounts of cocoa butter and discrepancies also appear with beef tallow or hydrogenated coconut oil diets. Controlled dietary experiments at the University of Minnesota and at 2 other centers, provide 63 sets of comparisons of serum cholesterol averages for groups of men on each of 2 chemically characterized diets. Least-squares analysis indicates that stearic acid, as well as saturated fatty acids containing fewer than 12 carbon atoms, have little or no effect on serum cholesterol in man. The equation, [DELTA] Chol. = 1. 2(2[DELTA]S[image] - AP) + 15[DELTA]Z, yields good correlation (r = 0.93) with the observed values in these 63 sets of data. This formulation also resolves heretofore puzzling discrepancies in the literature.