The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
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雌激素和雌激素样分子在神经发生和神经变性中的影响：有益还是有害？
DOI：
10.3389/fncel.2021.636176
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发表时间：
2021
影响因子：
5.3
通讯作者：
Bátiz LF
中科院分区：
文献类型：
--
作者：
Bustamante-Barrientos FA;Méndez-Ruette M;Ortloff A;Luz-Crawford P;Rivera FJ;Figueroa CD;Molina L;Bátiz LF
雌激素和雌激素样分子可以改变多种细胞类型的生物学特性。雌激素受体α（ERα）和β（ERβ）属于所谓的经典雌激素受体家族，而G蛋白偶联雌激素受体1（GPER-1）代表主要位于质膜的非经典雌激素受体。由于雌激素受体分布广泛，它们可以调节包括中枢神经系统（CNS）在内的多种组织和器官的细胞增殖、分化和存活。雌激素可以通过抗氧化剂、促进DNA修复、诱导生长因子的表达和调节脑血流来发挥神经保护作用。此外，雌激素依赖性信号通路参与调节神经干/祖细胞（NSPC）增殖和分化之间的平衡，从而影响神经发生过程。由于当今使用几种基于雌激素的疗法，并且包括植物雌激素和异雌激素在内的雌激素样分子在我们的环境中无所不在，因此细胞生物学和组织稳态的雌激素依赖性变化在人类健康和疾病中引起了人们的关注。本文对雌激素和雌激素样分子的当前知识及其对细胞存活和神经变性的影响，以及它们在 NSPC 增殖/分化平衡和神经发生中的作用进行了全面的文献综述。
Estrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1) represents a non-classical estrogen receptor mainly located in the plasma membrane. As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS). Estrogens can exert neuroprotective roles by acting as anti-oxidants, promoting DNA repair, inducing the expression of growth factors, and modulating cerebral blood flow. Additionally, estrogen-dependent signaling pathways are involved in regulating the balance between proliferation and differentiation of neural stem/progenitor cells (NSPCs), thus influencing neurogenic processes. Since several estrogen-based therapies are used nowadays and estrogen-like molecules, including phytoestrogens and xenoestrogens, are omnipresent in our environment, estrogen-dependent changes in cell biology and tissue homeostasis have gained attention in human health and disease. This article provides a comprehensive literature review on the current knowledge of estrogen and estrogen-like molecules and their impact on cell survival and neurodegeneration, as well as their role in NSPCs proliferation/differentiation balance and neurogenesis.
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影响因子：
11.4
作者：
Bellanti F;Matteo M;Rollo T;De Rosario F;Greco P;Vendemiale G;Serviddio G
通讯作者：
Serviddio G
影响因子：
4.2
作者：
Bethea CL;Kohama SG;Reddy AP;Urbanski HF
通讯作者：
Urbanski HF
影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
影响因子：
3.3
作者：
Barratt, H. E.;Budnick, H. C.;Nesic, O.
通讯作者：
Nesic, O.
寻找成人神经发生的根源。
影响因子：
64.5
作者：
Kheirbek MA
通讯作者：
Kheirbek MA