Physiologic cholestasis: elevation of the primary serum bile acid concentrations in normal infants.
Physiologic cholestasis: elevation of the primary serum bile acid concentrations in normal infants.
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DOI：
10.5555/uri:pii:0016508581900780
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发表时间：
1981
期刊：
影响因子：
29.4
通讯作者：
F. Suchy;W. Balistreri;J. Heubi;J. Searcy;R. Levin
中科院分区：
文献类型：
--
作者：
F. Suchy;W. Balistreri;J. Heubi;J. Searcy;R. Levin
肝排泄功能不成熟导致的“生理性胆汁淤积”可能发生在生命早期。血清胆汁酸应准确反映肠肝循环的成熟，因此，我们确定了正常婴儿的血清浓度的主要胆汁酸，以确定年龄相关的变化。有一个显着的上升，血清甘氨胆酸和鹅脱氧胆酸结合物在生命的头几天超过脐带血清中检测到的水平，达到的值显着大于最大餐后浓度发现在1岁以上的儿童（p <0.01）。胆汁酸浓度逐渐下降，但胆甘胺酸仍高于餐后值的年龄较大的儿童，直到4个月和鹅脱氧胆酸盐，直到6个月的年龄。在12名婴儿中，液体喂养刺激了更大的最大餐后甘胆酸浓度和积分餐下曲线下面积比儿童（p <0.01）。这些婴儿的鹅去氧胆酸盐餐后反应与老年受试者相比没有差异。我们的结论是，血清胆汁酸在正常婴儿升高，随后下降到儿童和成人的水平，表明在婴儿期肝功能的不断成熟。
Immaturity of hepatic excretory function resulting in a period of "physiologic cholestasis" may occur during early life. Serum bile acids should accurately reflect maturation of the enterohepatic circulation; we therefore determined serum concentrations of the primary bile acids in normal infants to define age-related changes. There was a striking rise in serum cholylglycine and conjugates of chenodeoxycholate during the first few days of life over levels detected in cord sera; the values attained were significantly greater than maximal postprandial concentrations found in children over 1 yr of age (p less than 0.01). There was a gradual decline in bile acid concentration; however cholylglycine remained higher than the postprandial values of older children until 4 mo and chenodeoxycholate until 6 mo of age. In 12 infants a liquid feeding stimulated a greater maximal postprandial cholylglycine concentration and integrated area under the meal curve than that achieved in children (p less than 0.01). There was no difference in the postprandial response in chenodeoxycholate in these infants compared with the older subjects. We conclude that serum bile acids are elevated in normal infants and that the subsequent decline to levels of the child and adult demonstrates the evolving maturation of liver function during infancy.