Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
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DOI：
10.1039/c9cc02554e
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发表时间：
2019-11-25
影响因子：
4.9
通讯作者：
Goss, Rebecca J. M.
中科院分区：
文献类型：
--
作者：
Renault, Yohann J. G.;Lynch, Rosemary;Goss, Rebecca J. M.
将合成生物学和合成化学相结合是研究复杂分子多样性的一种有效方法。为了进一步实现这一点，需要兼容的合成工具。我们报告的第一个Buchwald Hartwig胺化反应与未保护的卤代-Dahans在水性条件下，并证明这种方法也适用于未保护的三肽和天然产物barettin的修改。
Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halo-tryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin.