Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: A combined MRI and 1H-MRS study
Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: A combined MRI and 1H-MRS study
复制标题
DOI：
10.1016/j.neuroimage.2010.06.006
复制
发表时间：
2010-10-15
期刊：
影响因子：
5.7
通讯作者：
Gallinat, Juergen
中科院分区：
文献类型：
--
作者：
Klaer, Andreas Arthur;Ballmaier, Martina;Gallinat, Juergen
背景：磁共振成像(MRI)评估的体积缺陷和质子磁共振波谱(H-1-MRS)诊断的神经化学功能障碍(N-乙酰天冬氨酸，NAA)是精神分裂症患者海马区可靠的观察结果。NAA是谷氨酸合成途径中的一种重要的大脑氨基酸，被认为是精神分裂症症状学、组织学改变和脑体积缺陷的病理生物学核心。方法：对29例精神分裂症患者和44例正常受试者在3-Tesla扫描仪上进行了左侧海马区H-1-MRS和MRI体积测量的多模式成像研究。结果：与对照组相比，患者组的海马区体积显著减小，NAA浓度显著降低。精神分裂症患者海马区NAA浓度与体积呈显著负相关(r=-0.455，p=0.017)，而正常对照组则不存在。这些成像参数均与临床参数无关。结论：本研究结果提示精神分裂症患者海马区存在神经化学和结构缺陷。仅在患者中观察到的这两个参数之间的反向关系可能反映了神经化学和脑形态的相互作用，作为精神分裂症的一种病理生物学机制。这一观察结果与NAA在合成兴奋性神经递质中的重要作用以及谷氨酸对大脑形态的假设作用是一致的。测量的成像参数与临床参数的独立性符合精神分裂症的神经发育假说。(C)2010 Elsevier Inc.保留所有权利。
Background: Volume deficits assessed with magnetic resonance imaging (MRI) and neurochemical dysfunctions (N-acetylaspartate, NAA) diagnosed using proton MR spectroscopy (H-1-MRS) are reliable observations in the hippocampus of schizophrenic patients. NAA is an important cerebral amino acid in the synthesis pathways of glutamate, which has been implicated as a pathobiological core of schizophrenic symptomatology, of histological alterations and brain volume deficits in schizophrenia. However, the possible interaction between regional NAA reduction and volume deficits has been targeted only marginally in previous investigations.Methods: In 29 schizophrenic patients and 44 control subjects, a multimodal imaging study with H-1-MRS and MRI volumetry of the left hippocampus was performed on a 3-Tesla scanner.Results: Compared to the control group, the hippocampus of the patients exhibited a significant volume reduction and a significant NAA concentration decrease. In schizophrenic patients, but not in healthy controls, a significant negative correlation between hippocampal NAA concentration and volume (r = -0.455, p = 0.017) was observed. None of the imaging parameters was associated with clinical parameters.Conclusions: The results argue for a coexistent neurochemical and structural deficit in the hippocampus of schizophrenic patients. The inverse relationship between the two parameters observed in patients only may reflect an interaction of neurochemistry and brain morphology as a pathobiological mechanism in schizophrenia. This observation is compatible with the important role of NAA in the synthesis of excitatory neurotransmitters and the hypothesized role of glutamate for brain morphology. The independence of the measured imaging parameters from clinical parameters is in line with the neurodevelopmental hypothesis of schizophrenia. (C) 2010 Elsevier Inc. All rights reserved.