Deubiquitinases in the regulation of NF-κB signaling.
Deubiquitinases in the regulation of NF-κB signaling.
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作者：
核因子-κ B（NF-κB）是多种生物学功能的关键调节因子，包括先天性和适应性免疫以及细胞存活。NF-κB的活化受到严格调节，以排除可能导致持续性炎症和癌症的慢性信号传导。通过E3泛素连接酶对关键信号分子的泛素化已成为NF-κB信号传导的重要调节机制。去泛素化酶（DUB）抵消E3连接酶，因此在NF-κB信号转导和稳态的下调中起重要作用。了解特异性DUB如A20和CYLD下调NF-κB的机制可能为慢性炎症性疾病和癌症的治疗提供治疗机会。
Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly regulated to preclude chronic signaling that may lead to persistent inflammation and cancer. Ubiquitination of key signaling molecules by E3 ubiquitin ligases has emerged as an important regulatory mechanism for NF-κB signaling. Deubiquitinases (DUBs) counteract E3 ligases and therefore play a prominent role in the downregulation of NF-κB signaling and homeostasis. Understanding the mechanisms of NF-κB downregulation by specific DUBs such as A20 and CYLD may provide therapeutic opportunities for the treatment of chronic inflammatory diseases and cancer.
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影响因子：
32.4
作者：
Dejardin, E;Droin, NM;Green, DR
通讯作者：
Green, DR
DOI：
10.1016/j.bbamcr.2007.09.006
发表时间：
2008-05-01
影响因子：
5.1
作者：
Bohgaki, Miyuki;Tsukiyama, Tadasuke;Hatakeyama, Shigetsugu
通讯作者：
Hatakeyama, Shigetsugu
影响因子：
7.7
作者：
Boonyasrisawat, Watip;Eberle, Delphine;Doria, Alessandro
通讯作者：
Doria, Alessandro
影响因子：
16
作者：
Bertrand, Mathieu J. M.;Milutinovic, Snezana;Barker, Philip A.
通讯作者：
Barker, Philip A.
影响因子：
64.8
作者：
Brummelkamp, TR;Nijman, SMB;Bernards, R
通讯作者：
Bernards, R