Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation.
Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation.
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DOI：
10.2147/ijn.s119750
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发表时间：
2017
影响因子：
8
通讯作者：
Webster TJ
中科院分区：
文献类型：
--
作者：
Stolzoff M;Burns JE;Aslani A;Tobin EJ;Nguyen C;De La Torre N;Golshan NH;Ziemer KS;Webster TJ
钛是骨科植入物最广泛使用的材料之一，但它在短期和长期内表现出严重的并发症，主要是由于细胞-材料相互作用不良。在这些失败的许多模式中，植入部位的细菌感染随着耐药性细菌的增加而变得更加令人担忧。已经发现纳米结构化表面可以防止细菌在许多表面上定植，包括纳米纹理钛。在许多情况下，特定的纳米级粗糙度值和由此产生的表面能已被认为是“杀菌”，在这里，我们探索使用离子束蒸发作为一种新的技术来创建纳米级的地形特征，可以降低细菌密度。具体来说，我们研究了粗糙度与钛纳米特征形状和尺寸之间的关系，其中发现更小、间隔更规则的纳米特征（特别是40-50纳米高的峰间隔约0.25 μm）比单独具有高粗糙度值的表面具有更大的影响。
Titanium is one of the most widely used materials for orthopedic implants, yet it has exhibited significant complications in the short and long term, largely resulting from poor cell–material interactions. Among these many modes of failure, bacterial infection at the site of implantation has become a greater concern with the rise of antibiotic-resistant bacteria. Nanostructured surfaces have been found to prevent bacterial colonization on many surfaces, including nanotextured titanium. In many cases, specific nanoscale roughness values and resulting surface energies have been considered to be “bactericidal”; here, we explore the use of ion beam evaporation as a novel technique to create nanoscale topographical features that can reduce bacterial density. Specifically, we investigated the relationship between the roughness and titanium nanofeature shapes and sizes, in which smaller, more regularly spaced nanofeatures (specifically 40–50 nm tall peaks spaced ~0.25 μm apart) were found to have more effect than surfaces with high roughness values alone.