Effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats.
Effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats.
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偶然感染和免疫激活对实验性猫免疫缺陷病毒感染猫疾病进展的影响。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
Niels C Pedersen
中科院分区：
文献类型：
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作者：
G. Reubel;Gregg A. Dean;Jeanne W. George;J. Barlough;Niels C Pedersen
特定的病原体无猫实验感染猫免疫缺陷病毒（FIV），随后暴露于常见的传染性病原体和免疫刺激超过3年的时间。先前存在FIV感染的猫在暴露于猫血巴尔通体、刚地弓形虫、猫疱疹病毒-1和猫杯状病毒后表现出与非FIV感染猫相似的疾病体征，尽管它们更严重。在FIV感染或非FIV感染的猫中，未观察到灭活狂犬病病毒疫苗和合成聚脯氨酸免疫原免疫的不良反应，而白喉-破伤风-百日咳疫苗的应用在两组动物中均引起一过性发热和淋巴结病。与非FIV感染的猫相比，FIV感染的猫对病原体或免疫原的初级免疫应答通常延迟或减弱。反复感染和免疫激活对FIV特异性抗体的水平或含有FIV前病毒DNA的外周血单核细胞（PBMC）的比例没有显著影响。然而，在3年研究结束时，未暴露于免疫刺激物的FIV感染猫的CD 4 + T淋巴细胞数量和CD 4 +/CD 8 + T淋巴细胞比率低于暴露于辅助因子的FIV感染猫。后者也有正常水平的白细胞介素-3受体（IL-2 R）和主要组织相容性II类（MHC-II）抗原表达的PBMC，而FIV感染的猫没有暴露于辅因子上调IL-2 R和下调MHC-II抗原表达。得出的结论是，反复免疫刺激对FIV诱导的免疫缺陷的过程没有有害影响。
Specific pathogen-free cats were experimentally infected with feline immunodeficiency virus (FIV) and subsequently exposed to common infectious pathogens and immune stimuli over a 3-year period. Cats with preexisting FIV infection showed signs of disease after exposure to Haemobartonella felis, Toxoplasma gondii, feline herpesvirus-1, and feline calicivirus similar to signs in non-FIV-infected cats, although they were more severe. No adverse effects of immunization with inactivated rabies virus vaccine and a synthetic polyproline immunogen were observed in either FIV-infected or non-FIV-infected cats, whereas the application of a diphtheria-tetanus-pertussis vaccine caused transient fever and lymphadenopathy in both groups of animals. Primary immune responses to pathogens or immunogens were usually delayed or diminished in FIV-infected compared with non-FIV-infected cats. Repeated infections and immune activation had no significant effects on the levels of FIV-specific antibodies or on the proportion of peripheral blood mononuclear cells (PBMCs) containing FIV proviral DNA. However, FIV-infected cats that were not exposed to immune stimuli had lower CD4+ T-lymphocyte numbers and lower CD4+/CD8+ T lymphocyte ratios at the end of the 3-year study than FIV-infected cats exposed to cofactors. The latter also had normal levels of interleukin-3 receptor (IL-2R) and major histocompatibility class II (MHC-II) antigen expression on PBMCs, while FIV-infected cats not exposed to cofactors had up-regulated IL-2R and down-regulated MHC-II antigen expression. It was concluded that repeated immune stimulation did not have a deleterious effect on the course of FIV-induced immunodeficiency.